Proteolytic maturation of α2δ controls the probability of synaptic vesicular release

Auxiliary α2δ subunits are important proteins for trafficking of voltage-gated calcium channels (CaV) at the active zones of synapses. We have previously shown that the post-translational proteolytic cleavage of α2δ is essential for their modulatory effects on the trafficking of N-type (CaV2.2) calc...

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Bibliographic Details
Main Authors: Laurent Ferron, Ivan Kadurin, Annette C Dolphin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/37507