New Evidence on a Distinction between Aβ40 and Aβ42 Amyloids: Thioflavin T Binding Modes, Clustering Tendency, Degradation Resistance, and Cross-Seeding

New Evidence on a Distinction between Aβ40 and Aβ42 Amyloids: Thioflavin T Binding Modes, Clustering Tendency, Degradation Resistance, and Cross-Seeding

The relative abundance of two main Abeta-peptide types with different lengths, Aβ40 and Aβ42, determines the severity of the Alzheimer’s disease progression. However, the factors responsible for different behavior patterns of these peptides in the amyloidogenesis process remain unknown. In this comp...

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Bibliographic Details
Main Authors: Anna I. Sulatskaya, Georgy N. Rychkov, Maksim I. Sulatsky, Ekaterina V. Mikhailova, Nadezhda M. Melnikova, Veronika S. Andozhskaya, Irina M. Kuznetsova, Konstantin K. Turoverov
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
amyloid fibrils
Abeta peptide
seeding and cross-seeding
structure
stability and cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/23/10/5513

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