Gender issues in antiepileptic drug treatment
The purpose of this review is to discuss gender-related aspects in the, pharmacokinetics, effects, selection and use of antiepileptic drugs (AED). In general, there are few known gender related differences in pharmacokinetics or efficacy of AEDs. Conversely, gender has a significant influence on the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-12-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996114001296 |
| _version_ | 1818611064782192640 |
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| author | Emilio Perucca Dina Battino Torbjörn Tomson |
| author_facet | Emilio Perucca Dina Battino Torbjörn Tomson |
| author_sort | Emilio Perucca |
| collection | DOAJ |
| description | The purpose of this review is to discuss gender-related aspects in the, pharmacokinetics, effects, selection and use of antiepileptic drugs (AED). In general, there are few known gender related differences in pharmacokinetics or efficacy of AEDs. Conversely, gender has a significant influence on the susceptibility to certain adverse effects, not the least those involving alterations in sex hormone metabolism. Particularly relevant are the teratogenic effects of AEDs, with important differences among AEDs in their potential to cause adverse effects on the fetus when used during pregnancy. Pregnancy can also markedly affect the pharmacokinetics of several AEDs, and dose adjustments are often needed during pregnancy to maintain seizure control. Some treatments that are used only by women, such as contraceptive steroids and hormone replacement therapy, can also interact with AEDs to an extent that may affect the utilization of both the AEDs and the other drug. |
| first_indexed | 2024-12-16T15:24:23Z |
| format | Article |
| id | doaj.art-65aefc50b4af479cb8ce04ad01132356 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-16T15:24:23Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-65aefc50b4af479cb8ce04ad011323562022-12-21T22:26:32ZengElsevierNeurobiology of Disease1095-953X2014-12-0172217223Gender issues in antiepileptic drug treatmentEmilio Perucca0Dina Battino1Torbjörn Tomson2Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; C. Mondino National Neurological Institute, Pavia, ItalyEpilepsy Centre, Department of Neurophysiology and Experimental Epileptology, Istituto di Ricovero a Cura Carattere Scientifico (IRCCS), Neurological Institute “Carlo Besta” Foundation, Milan, ItalyDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Corresponding author at: Department of Neurology, Karolinska University Hospital, SE 171 76 Stockholm, Sweden. Fax: +46 851773757.The purpose of this review is to discuss gender-related aspects in the, pharmacokinetics, effects, selection and use of antiepileptic drugs (AED). In general, there are few known gender related differences in pharmacokinetics or efficacy of AEDs. Conversely, gender has a significant influence on the susceptibility to certain adverse effects, not the least those involving alterations in sex hormone metabolism. Particularly relevant are the teratogenic effects of AEDs, with important differences among AEDs in their potential to cause adverse effects on the fetus when used during pregnancy. Pregnancy can also markedly affect the pharmacokinetics of several AEDs, and dose adjustments are often needed during pregnancy to maintain seizure control. Some treatments that are used only by women, such as contraceptive steroids and hormone replacement therapy, can also interact with AEDs to an extent that may affect the utilization of both the AEDs and the other drug.http://www.sciencedirect.com/science/article/pii/S0969996114001296EpilepsyAntiepileptic drugsGenderPharmacokineticsPregnancyMenopause |
| spellingShingle | Emilio Perucca Dina Battino Torbjörn Tomson Gender issues in antiepileptic drug treatment Neurobiology of Disease Epilepsy Antiepileptic drugs Gender Pharmacokinetics Pregnancy Menopause |
| title | Gender issues in antiepileptic drug treatment |
| title_full | Gender issues in antiepileptic drug treatment |
| title_fullStr | Gender issues in antiepileptic drug treatment |
| title_full_unstemmed | Gender issues in antiepileptic drug treatment |
| title_short | Gender issues in antiepileptic drug treatment |
| title_sort | gender issues in antiepileptic drug treatment |
| topic | Epilepsy Antiepileptic drugs Gender Pharmacokinetics Pregnancy Menopause |
| url | http://www.sciencedirect.com/science/article/pii/S0969996114001296 |
| work_keys_str_mv | AT emilioperucca genderissuesinantiepilepticdrugtreatment AT dinabattino genderissuesinantiepilepticdrugtreatment AT torbjorntomson genderissuesinantiepilepticdrugtreatment |