Mechanism for inverted-repeat recombination induced by a replication fork barrier
Replication stress and abundant repetitive sequences have emerged as primary conditions underlying genomic instability in eukaryotes. Here the authors use a prokaryotic Tus/Ter barrier designed to induce transient replication fork stalling near inverted repeats in the budding yeast genome to support...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27443-w |
| _version_ | 1798026498605580288 |
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| author | Léa Marie Lorraine S. Symington |
| author_facet | Léa Marie Lorraine S. Symington |
| author_sort | Léa Marie |
| collection | DOAJ |
| description | Replication stress and abundant repetitive sequences have emerged as primary conditions underlying genomic instability in eukaryotes. Here the authors use a prokaryotic Tus/Ter barrier designed to induce transient replication fork stalling near inverted repeats in the budding yeast genome to support a model for recombination of closely linked repeats at stalled replication forks. |
| first_indexed | 2024-04-11T18:36:25Z |
| format | Article |
| id | doaj.art-65af69db9b8e4824939384839f1c4762 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T18:36:25Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-65af69db9b8e4824939384839f1c47622022-12-22T04:09:15ZengNature PortfolioNature Communications2041-17232022-01-0113111310.1038/s41467-021-27443-wMechanism for inverted-repeat recombination induced by a replication fork barrierLéa Marie0Lorraine S. Symington1Department of Microbiology & Immunology, Columbia University Irving Medical CenterDepartment of Microbiology & Immunology, Columbia University Irving Medical CenterReplication stress and abundant repetitive sequences have emerged as primary conditions underlying genomic instability in eukaryotes. Here the authors use a prokaryotic Tus/Ter barrier designed to induce transient replication fork stalling near inverted repeats in the budding yeast genome to support a model for recombination of closely linked repeats at stalled replication forks.https://doi.org/10.1038/s41467-021-27443-w |
| spellingShingle | Léa Marie Lorraine S. Symington Mechanism for inverted-repeat recombination induced by a replication fork barrier Nature Communications |
| title | Mechanism for inverted-repeat recombination induced by a replication fork barrier |
| title_full | Mechanism for inverted-repeat recombination induced by a replication fork barrier |
| title_fullStr | Mechanism for inverted-repeat recombination induced by a replication fork barrier |
| title_full_unstemmed | Mechanism for inverted-repeat recombination induced by a replication fork barrier |
| title_short | Mechanism for inverted-repeat recombination induced by a replication fork barrier |
| title_sort | mechanism for inverted repeat recombination induced by a replication fork barrier |
| url | https://doi.org/10.1038/s41467-021-27443-w |
| work_keys_str_mv | AT leamarie mechanismforinvertedrepeatrecombinationinducedbyareplicationforkbarrier AT lorrainessymington mechanismforinvertedrepeatrecombinationinducedbyareplicationforkbarrier |