THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE
Objective: To evaluate the contribution of IL1β gene polymorphisms rs1143634 and rs16944 in the development of myocardial infarction (MI) and multivessel coronary artery disease in patients with CAD. Material and Methods: 303 patients with stable coronary artery disease were included in the study. S...
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2016-09-01
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| Series: | Атеросклероз |
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| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/18/18 |
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| author | O. L. Barbarash J. V. Bairakova A. V. Ponasenko M. V. Khutornaya A. A. Kuzmina Y. V. Kazachek L. S. Barbarash |
| author_facet | O. L. Barbarash J. V. Bairakova A. V. Ponasenko M. V. Khutornaya A. A. Kuzmina Y. V. Kazachek L. S. Barbarash |
| author_sort | O. L. Barbarash |
| collection | DOAJ |
| description | Objective: To evaluate the contribution of IL1β gene polymorphisms rs1143634 and rs16944 in the development of myocardial infarction (MI) and multivessel coronary artery disease in patients with CAD. Material and Methods: 303 patients with stable coronary artery disease were included in the study. Serum IL1β levels were measured with commercial kits (Bender MedSystems, Austria). TaqMan genotyping assays were performed in 96-well plate. Results: Women, who were homozygous carriers of the IL-1β rs1143634 G major allele, had a 4-fold decreased risk of developing multivessel coronary artery disease (p = 0.046) as well as a 2-fold decreased risk of myocardial infarction (p = 0.0198). The variable site of the IL1β rs1143634 was significantly (p = 0.0025) associated with a reduced risk of MI according to the dominant inheritance pattern (OR = 0.48, 95% CI = 0.29- 0.77), and rs16944 - with a five-fold increased risk (p = 0.0022) according to the co-dominant model (OR = 5.12, 95% CI = 1.82-14.42). The risk of myocardial infarction in men, who were homozygous carriers of the IL1β rs16944 T minor allele, was six times higher than that in women (p = 0.0093). The AC haplotype (rs1143634- rs16944) was associated with a 2-fold reduced risk of myocardial infarction and PICS (OR = 0.49, 95% CI = 0.29-0.81, p <0.0059), with the most pronounced effects in the age of 65 years (p = 0.0031). However, the GT haplotype rs1143634-rs16944 in younger patients (<65 years) was associated with the development of myocardial infarction (p = 0.0074). Conclusion: Genetic markers should be taken into consideration as an independent predictors of myocardial infarction and multivessel coronary artery disease. |
| first_indexed | 2024-04-11T01:23:49Z |
| format | Article |
| id | doaj.art-65b200c4a0ab4d348dcc579bfc672d3d |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:23:49Z |
| publishDate | 2016-09-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-65b200c4a0ab4d348dcc579bfc672d3d2023-01-03T10:50:23ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2016-09-01123514THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASEO. L. Barbarash0J. V. Bairakova1A. V. Ponasenko2M. V. Khutornaya3A. A. Kuzmina4Y. V. Kazachek5 L. S. Barbarash6Research Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationResearch Institute for Complex Issues of Cardiovascular Diseases Russian FederationObjective: To evaluate the contribution of IL1β gene polymorphisms rs1143634 and rs16944 in the development of myocardial infarction (MI) and multivessel coronary artery disease in patients with CAD. Material and Methods: 303 patients with stable coronary artery disease were included in the study. Serum IL1β levels were measured with commercial kits (Bender MedSystems, Austria). TaqMan genotyping assays were performed in 96-well plate. Results: Women, who were homozygous carriers of the IL-1β rs1143634 G major allele, had a 4-fold decreased risk of developing multivessel coronary artery disease (p = 0.046) as well as a 2-fold decreased risk of myocardial infarction (p = 0.0198). The variable site of the IL1β rs1143634 was significantly (p = 0.0025) associated with a reduced risk of MI according to the dominant inheritance pattern (OR = 0.48, 95% CI = 0.29- 0.77), and rs16944 - with a five-fold increased risk (p = 0.0022) according to the co-dominant model (OR = 5.12, 95% CI = 1.82-14.42). The risk of myocardial infarction in men, who were homozygous carriers of the IL1β rs16944 T minor allele, was six times higher than that in women (p = 0.0093). The AC haplotype (rs1143634- rs16944) was associated with a 2-fold reduced risk of myocardial infarction and PICS (OR = 0.49, 95% CI = 0.29-0.81, p <0.0059), with the most pronounced effects in the age of 65 years (p = 0.0031). However, the GT haplotype rs1143634-rs16944 in younger patients (<65 years) was associated with the development of myocardial infarction (p = 0.0074). Conclusion: Genetic markers should be taken into consideration as an independent predictors of myocardial infarction and multivessel coronary artery disease.https://ateroskleroz.elpub.ru/jour/article/view/18/18rs16944myocardial infarctionmultivessel coronary artery diseaseinterleukin - il1β gene polymorphic sites il1β rs1143634 |
| spellingShingle | O. L. Barbarash J. V. Bairakova A. V. Ponasenko M. V. Khutornaya A. A. Kuzmina Y. V. Kazachek L. S. Barbarash THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE Атеросклероз rs16944 myocardial infarction multivessel coronary artery disease interleukin - il1β gene polymorphic sites il1β rs1143634 |
| title | THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE |
| title_full | THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE |
| title_fullStr | THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE |
| title_full_unstemmed | THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE |
| title_short | THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE |
| title_sort | role of il1β candidate gene polymorphisms in the occurrence of myocardial infarction and multivessel disease in patients with coronary artery disease |
| topic | rs16944 myocardial infarction multivessel coronary artery disease interleukin - il1β gene polymorphic sites il1β rs1143634 |
| url | https://ateroskleroz.elpub.ru/jour/article/view/18/18 |
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