Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction
The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buff...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2010-06-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200002 |
| _version_ | 1828291783606403072 |
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| author | Anapaula Sommer Vinagre Ângela Della'Santa Rubio Origuella Rönnau Sabrina Francisco Pereira Lídia Uliano da Silveira Elenir de Fátima Wiilland Edna Sayuri Suyenaga |
| author_facet | Anapaula Sommer Vinagre Ângela Della'Santa Rubio Origuella Rönnau Sabrina Francisco Pereira Lídia Uliano da Silveira Elenir de Fátima Wiilland Edna Sayuri Suyenaga |
| author_sort | Anapaula Sommer Vinagre |
| collection | DOAJ |
| description | The objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.<br>O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários. |
| first_indexed | 2024-04-13T10:56:25Z |
| format | Article |
| id | doaj.art-65b25365ee0c4dcda946ab3ca9399a43 |
| institution | Directory Open Access Journal |
| issn | 1984-8250 2175-9790 |
| language | English |
| last_indexed | 2024-04-13T10:56:25Z |
| publishDate | 2010-06-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-65b25365ee0c4dcda946ab3ca9399a432022-12-22T02:49:30ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences1984-82502175-97902010-06-0146216917710.1590/S1984-82502010000200002Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoctionAnapaula Sommer VinagreÂngela Della'Santa Rubio Origuella RönnauSabrina Francisco PereiraLídia Uliano da SilveiraElenir de Fátima WiillandEdna Sayuri SuyenagaThe objective of this research was to identify the effects of 3-week treatment of normal and streptozotocin-induced diabetic rats using a leaf decoction of Campomanesia xanthocarpa Berg. (20 g/L) on physiological, biochemical and histological parameters. Streptozotocin (STZ, 70 mg/kg in citrate buffer, pH 4.5) was administered IP to induce experimental diabetes one week prior to the treatment. STZ caused typical diabetic symptoms: polydypsia, polyuria, polyphagia, hyperglycemia, hypertriglyceridemia and histopathological modifications in the pancreas, liver and kidney. The treatment of diabetic rats using the decoction decreased blood glucose levels, inhibited hepatic glycogen loss, and prevented potential histopathological alterations in the pancreas and kidneys. No differences were found between the control rats treated with the decoction and the control rats maintained on water only. In conclusion, these results suggest that C. xanthocarpa leaf decoction (20g/L) might be useful for diabetes mellitus management, but further pharmacological and toxicological studies are needed.<br>O objetivo deste trabalho foi identificar os efeitos do tratamento com o decocto das folhas de Campomanesia xanthocarpa Berg. (20 g/L), durante 3 semanas, sobre parâmetros fisiológicos, bioquímicos e histológicos de ratos normais e diabéticos induzidos por estreptozotocina. O diabete melito foi induzido uma semana antes de iniciar o tratamento experimental, pela administração IP de estreptozotocina (STZ, 70 mg/kg em tampão citrato, pH 4.5). Os ratos tratados com STZ apresentaram sintomas típicos de diabete: polifagia, polidipsia, hiperglicemia, hipertrigliceridemia e alterações histopatológicas no pâncreas, fígado e rim. O tratamento dos ratos diabéticos com o decocto diminuiu os níveis de glicose sanguínea, inibiu a degradação do glicogênio hepático e preveniu possíveis alterações histopatológicas no pâncreas e no rim. Nos ratos controles tratados com o decocto não foram verificadas diferenças significativas em relação aos controles tratados com água. Em conclusão, os resultados sugerem que o tratamento com o decocto das folhas de C. xanthocarpa leaf decoction (20 g/L) possa ser útil para o manejo do diabete melito, porém estudos farmacológicos e toxicológicos ainda são necessários.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200002Campomanesia xanthocarpaDiabete MelitoPlanta hipoglicemianteCarboidratosLipídeosCampomanesia xanthocarpaDiabetes MellitusHypoglycemic plantHistologyCarbohydrateLipid |
| spellingShingle | Anapaula Sommer Vinagre Ângela Della'Santa Rubio Origuella Rönnau Sabrina Francisco Pereira Lídia Uliano da Silveira Elenir de Fátima Wiilland Edna Sayuri Suyenaga Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction Brazilian Journal of Pharmaceutical Sciences Campomanesia xanthocarpa Diabete Melito Planta hipoglicemiante Carboidratos Lipídeos Campomanesia xanthocarpa Diabetes Mellitus Hypoglycemic plant Histology Carbohydrate Lipid |
| title | Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction |
| title_full | Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction |
| title_fullStr | Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction |
| title_full_unstemmed | Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction |
| title_short | Anti-diabetic effects of Campomanesia xanthocarpa (Berg) leaf decoction |
| title_sort | anti diabetic effects of campomanesia xanthocarpa berg leaf decoction |
| topic | Campomanesia xanthocarpa Diabete Melito Planta hipoglicemiante Carboidratos Lipídeos Campomanesia xanthocarpa Diabetes Mellitus Hypoglycemic plant Histology Carbohydrate Lipid |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200002 |
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