Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder
Background: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause ab...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00764/full |
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| author | Beatrix Feigl Beatrix Feigl Beatrix Feigl Govinda Ojha Govinda Ojha Leanne Hides Andrew J. Zele Andrew J. Zele |
| author_facet | Beatrix Feigl Beatrix Feigl Beatrix Feigl Govinda Ojha Govinda Ojha Leanne Hides Andrew J. Zele Andrew J. Zele |
| author_sort | Beatrix Feigl |
| collection | DOAJ |
| description | Background: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause abberant transmission of the external illumination for photoentrainment. It is not known if patients with non-seasonal depression have abnormal melanospin mediated signaling and/or irregular environmental light exposure.Methods: Twenty-one adults who live in a sub-tropical region, including eight patients with non-seasonal depression and thirteen age-matched healthy controls were recruited. The Mini International Neuropsychiatry Interview diagnosed the presence of a major depressive disorder. Light exposure was determined using actigraphy over a 2 week period. The melanopsin mediated post-illumination pupil response (PIPR) and outer retinal inputs to ipRGCs (transient pupil response and maximum pupil constriction amplitude) were measured in response to 1 s, short and long wavelength light with high and low melanopsin excitation.Results: The mean daylight exposure as a function of clock hours and total light exposure duration (mins) to illumination levels commonly recommended for depression therapy were not significantly different between groups. Out of 84 pupil measurements (42 each in the depression and control groups), the melanopsin-mediated PIPR amplitude, transient pupil response, and pupil constriction amplitude were not significantly different between groups.Conclusions: This report provides initial evidence of normal melanopsin function and environmental light exposures in patients with pre-dominately mid and moderate non-seasonal depression in a subtropical location in the southern hemisphere. |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T22:30:35Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-65b288f05d7e4c82b3da7a1fdaf9b2722022-12-22T03:13:59ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-09-01910.3389/fneur.2018.00764408000Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive DisorderBeatrix Feigl0Beatrix Feigl1Beatrix Feigl2Govinda Ojha3Govinda Ojha4Leanne Hides5Andrew J. Zele6Andrew J. Zele7Medical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaQueensland Eye Institute, Brisbane, QLD, AustraliaMedical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Psychology, University of Queensland, Brisbane, QLD, AustraliaMedical Retina and Visual Science Laboratories, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, AustraliaSchool of Optometry and Vision Science, Queensland University of Technology, Brisbane, QLD, AustraliaBackground: Melanopsin-expressing intrinsically photosensitive Retinal Ganglion Cells (ipRGCs) signal non-imaging forming effects of environmental light for circadian phoentrainment, the pupil light reflex, and mood regulation. In seasonal affective disorder, ipRGC dysfunction is thought to cause abberant transmission of the external illumination for photoentrainment. It is not known if patients with non-seasonal depression have abnormal melanospin mediated signaling and/or irregular environmental light exposure.Methods: Twenty-one adults who live in a sub-tropical region, including eight patients with non-seasonal depression and thirteen age-matched healthy controls were recruited. The Mini International Neuropsychiatry Interview diagnosed the presence of a major depressive disorder. Light exposure was determined using actigraphy over a 2 week period. The melanopsin mediated post-illumination pupil response (PIPR) and outer retinal inputs to ipRGCs (transient pupil response and maximum pupil constriction amplitude) were measured in response to 1 s, short and long wavelength light with high and low melanopsin excitation.Results: The mean daylight exposure as a function of clock hours and total light exposure duration (mins) to illumination levels commonly recommended for depression therapy were not significantly different between groups. Out of 84 pupil measurements (42 each in the depression and control groups), the melanopsin-mediated PIPR amplitude, transient pupil response, and pupil constriction amplitude were not significantly different between groups.Conclusions: This report provides initial evidence of normal melanopsin function and environmental light exposures in patients with pre-dominately mid and moderate non-seasonal depression in a subtropical location in the southern hemisphere.https://www.frontiersin.org/article/10.3389/fneur.2018.00764/fullpupilmelanopsinlight exposuredepressionMDD = major depressive disorder |
| spellingShingle | Beatrix Feigl Beatrix Feigl Beatrix Feigl Govinda Ojha Govinda Ojha Leanne Hides Andrew J. Zele Andrew J. Zele Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder Frontiers in Neurology pupil melanopsin light exposure depression MDD = major depressive disorder |
| title | Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder |
| title_full | Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder |
| title_fullStr | Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder |
| title_full_unstemmed | Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder |
| title_short | Melanopsin-Driven Pupil Response and Light Exposure in Non-seasonal Major Depressive Disorder |
| title_sort | melanopsin driven pupil response and light exposure in non seasonal major depressive disorder |
| topic | pupil melanopsin light exposure depression MDD = major depressive disorder |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00764/full |
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