Low seroprevalence of hepatitis E on Reunion island
Objective: Hepatitis E virus (HEV) has been scarcely investigated in the Indian Ocean. Following a nationwide serosurvey among blood donors, we conducted a population-based serosurvey to assess the magnitude of HEV exposure on Reunion Island. Methods: Four hundred and sixty-six archived frozen human...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | One Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771419300473 |
| _version_ | 1811306257716346880 |
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| author | Patrick Gérardin Vincent Porphyre Anita Tsatoromila Laurent Cuissard Jean-Philippe Becquart Karim Boussaid Antoine Bertolotti Florence Naze Sandrine Picot Laurent Filleul Pablo Tortosa Julien Jaubert Vanina Guernier Hervé Pascalis |
| author_facet | Patrick Gérardin Vincent Porphyre Anita Tsatoromila Laurent Cuissard Jean-Philippe Becquart Karim Boussaid Antoine Bertolotti Florence Naze Sandrine Picot Laurent Filleul Pablo Tortosa Julien Jaubert Vanina Guernier Hervé Pascalis |
| author_sort | Patrick Gérardin |
| collection | DOAJ |
| description | Objective: Hepatitis E virus (HEV) has been scarcely investigated in the Indian Ocean. Following a nationwide serosurvey among blood donors, we conducted a population-based serosurvey to assess the magnitude of HEV exposure on Reunion Island. Methods: Four hundred and sixty-six archived frozen human sera from the 2009 CoPanFlu-RUN cohort were analysed using the Wantai HEV IgG enzyme immunoassay. HEV seropositivity was defined as an IgG titre ≥5 UI/ml. Raw and weighted seroprevalences were assessed to account for the discrepancy between the CoPanFlu-RUN subset and the general community. Prevalence proportion ratios (PPR) were measured using log-binomial models. Results: The raw and the weighted seroprevalences of HEV were 9.01% (95% CI 6.41–11.61) and 6.73% (95% CI 4.47–8.98), respectively. The presence of HEV IgG antibodies was associated with increasing age (P < 0.001). In a survey-adjusted model minimizing the sampling bias and adjusting for age, males were more likely to be seropositive than females (adjusted PPR 2.59, 95% CI 1.07–6.25). Seropositivity was spatially heterogeneous across the island (P < 0.01). Living in the neighbourhood of a pig farm within a low to intermediate slope area was associated with seropositivity in several models adjusting for age, gender, altitude of residency and interaction between slope and pig farms. Conclusion: Reunion Island is a low endemic area for HEV exposure. Despite limitations related to the retrospective study design, our findings confirm the roles of cumulative lifetime exposure and male gender in HEV exposure. The risk associated with neighbouring pig farms might also suggest environmental contamination in this setting. Keywords: Serology, Immunoassay, Seroepidemiological study, Serosurvey, Stored frozen serum, Hepatitis E, Pig farm, Zoonosis, Prevalence, General population |
| first_indexed | 2024-04-13T08:41:08Z |
| format | Article |
| id | doaj.art-65b36133c2924b8180c8001249fd3449 |
| institution | Directory Open Access Journal |
| issn | 2352-7714 |
| language | English |
| last_indexed | 2024-04-13T08:41:08Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj.art-65b36133c2924b8180c8001249fd34492022-12-22T02:53:53ZengElsevierOne Health2352-77142019-12-018Low seroprevalence of hepatitis E on Reunion islandPatrick Gérardin0Vincent Porphyre1Anita Tsatoromila2Laurent Cuissard3Jean-Philippe Becquart4Karim Boussaid5Antoine Bertolotti6Florence Naze7Sandrine Picot8Laurent Filleul9Pablo Tortosa10Julien Jaubert11Vanina Guernier12Hervé Pascalis13INSERM Centre d'Investigation Clinique 1410 Epidémiologie Clinique, Centre Hospitalier Universitaire (CHU), Réunion, Saint Pierre, Reunion; UM 134 PIMIT Processus Infectieux en Milieu Insulaire Tropical. Université de La Réunion, INSERM 1187, CNRS 9192, IRD 249, CYROI, Sainte Clotilde, Reunion; Corresponding author at: INSERM CIC 1410, CHU Réunion, GHSR, BP 350, 97448 Saint Pierre Cedex, Reunion, France.UMR SELMET, Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Saint Pierre, Reunion, UMR SELMET, Université de Montpellier, CIRAD, INRA, Montpellier SupAgro, Montpellier, FranceLaboratoire de Microbiologie, CHU Réunion, Saint Denis, Saint Pierre, ReunionService d'Hépato-Gastroentérologie, Centre Hospitalier de l'Ouest Réunion, Saint Paul, ReunionService d'Hépato-Gastroentérologie, CHU Réunion, Saint Pierre, ReunionINSERM Centre d'Investigation Clinique 1410 Epidémiologie Clinique, Centre Hospitalier Universitaire (CHU), Réunion, Saint Pierre, ReunionINSERM Centre d'Investigation Clinique 1410 Epidémiologie Clinique, Centre Hospitalier Universitaire (CHU), Réunion, Saint Pierre, Reunion; Service des Maladies Infectieuses, CHU de la Réunion, Saint Pierre, ReunionLaboratoire de Microbiologie, CHU Réunion, Saint Denis, Saint Pierre, ReunionLaboratoire de Microbiologie, CHU Réunion, Saint Denis, Saint Pierre, ReunionCellule d'Intervention Régionale et d'Epidémiologie Océan Indien, Santé Publique France, French National Public Health Agency, Saint Denis, ReunionUM 134 PIMIT Processus Infectieux en Milieu Insulaire Tropical. Université de La Réunion, INSERM 1187, CNRS 9192, IRD 249, CYROI, Sainte Clotilde, ReunionLaboratoire de Microbiologie, CHU Réunion, Saint Denis, Saint Pierre, ReunionGeelong Centre for Emerging Infectious Diseases, Deakin University, Geelong, Victoria, AustraliaUM 134 PIMIT Processus Infectieux en Milieu Insulaire Tropical. Université de La Réunion, INSERM 1187, CNRS 9192, IRD 249, CYROI, Sainte Clotilde, ReunionObjective: Hepatitis E virus (HEV) has been scarcely investigated in the Indian Ocean. Following a nationwide serosurvey among blood donors, we conducted a population-based serosurvey to assess the magnitude of HEV exposure on Reunion Island. Methods: Four hundred and sixty-six archived frozen human sera from the 2009 CoPanFlu-RUN cohort were analysed using the Wantai HEV IgG enzyme immunoassay. HEV seropositivity was defined as an IgG titre ≥5 UI/ml. Raw and weighted seroprevalences were assessed to account for the discrepancy between the CoPanFlu-RUN subset and the general community. Prevalence proportion ratios (PPR) were measured using log-binomial models. Results: The raw and the weighted seroprevalences of HEV were 9.01% (95% CI 6.41–11.61) and 6.73% (95% CI 4.47–8.98), respectively. The presence of HEV IgG antibodies was associated with increasing age (P < 0.001). In a survey-adjusted model minimizing the sampling bias and adjusting for age, males were more likely to be seropositive than females (adjusted PPR 2.59, 95% CI 1.07–6.25). Seropositivity was spatially heterogeneous across the island (P < 0.01). Living in the neighbourhood of a pig farm within a low to intermediate slope area was associated with seropositivity in several models adjusting for age, gender, altitude of residency and interaction between slope and pig farms. Conclusion: Reunion Island is a low endemic area for HEV exposure. Despite limitations related to the retrospective study design, our findings confirm the roles of cumulative lifetime exposure and male gender in HEV exposure. The risk associated with neighbouring pig farms might also suggest environmental contamination in this setting. Keywords: Serology, Immunoassay, Seroepidemiological study, Serosurvey, Stored frozen serum, Hepatitis E, Pig farm, Zoonosis, Prevalence, General populationhttp://www.sciencedirect.com/science/article/pii/S2352771419300473 |
| spellingShingle | Patrick Gérardin Vincent Porphyre Anita Tsatoromila Laurent Cuissard Jean-Philippe Becquart Karim Boussaid Antoine Bertolotti Florence Naze Sandrine Picot Laurent Filleul Pablo Tortosa Julien Jaubert Vanina Guernier Hervé Pascalis Low seroprevalence of hepatitis E on Reunion island One Health |
| title | Low seroprevalence of hepatitis E on Reunion island |
| title_full | Low seroprevalence of hepatitis E on Reunion island |
| title_fullStr | Low seroprevalence of hepatitis E on Reunion island |
| title_full_unstemmed | Low seroprevalence of hepatitis E on Reunion island |
| title_short | Low seroprevalence of hepatitis E on Reunion island |
| title_sort | low seroprevalence of hepatitis e on reunion island |
| url | http://www.sciencedirect.com/science/article/pii/S2352771419300473 |
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