Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells

Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells

Multidrug-resistance is a major obstacle facing cancer chemotherapy. This paper demonstrates that novel compound Ophiobolin-O reverses MCF-7/ADR resistance to adriamycin (ADM). The IC50 of ADM treated MCF-7 cells was 2.02 ± 0.05 µM and 74.00 ± 0.18 µM treated MCF-7/ADR cells, about 37-fold, compared...

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Bibliographic Details
Main Authors: Weiming Zhu, Caiguo Huang, Kui Hong, Jieyin Sun, Shanjian Wei, Xue Yang, Tonghan Zhu, Cuiting Lv, Wenxia Sun
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Marine Drugs
Subjects:
Ophiobolin-O
adriamycin (ADM)
drug resistance reversal
Online Access:http://www.mdpi.com/1660-3397/11/11/4570

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