Sleep-wake dynamics pre- and post-exposure to chronic social stress
Summary: An analytical approach combining the statistical distributions of the sleep-wake bouts and the Markov transition matrix is used to explain the under-examined association between the microarchitecture of the sleep-wake cycle and susceptibility to chronic social stress in C57BL/6J mice. We se...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422101172X |
| _version_ | 1819292073774284800 |
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| author | Basma Radwan Gloria Jansen Dipesh Chaudhury |
| author_facet | Basma Radwan Gloria Jansen Dipesh Chaudhury |
| author_sort | Basma Radwan |
| collection | DOAJ |
| description | Summary: An analytical approach combining the statistical distributions of the sleep-wake bouts and the Markov transition matrix is used to explain the under-examined association between the microarchitecture of the sleep-wake cycle and susceptibility to chronic social stress in C57BL/6J mice. We separated the sleep-wake transitions into distinct sleep-wake sequences, NREM↔Wake and NREM→REM→Wake, which are controlled by independent neural circuits. Our findings imply greater pull toward the wake leading to early termination and fragmentation of the sleep bouts in the light in both sleep-wake sequences pre- and post-stress. Moreover, the stability of NREM in the NREM↔Wake transition was lower, and the probability of transitioning to wake was higher in susceptible relative to resilient or stress-naïve mice pre- and post-stress. Our findings help elucidate the mechanistic interplay between sleep and mood by suggesting the potential neural underpinnings of sleep disturbances responsible the aberrant transitions of sleep-wake bouts exhibited by the stress-susceptible phenotype. |
| first_indexed | 2024-12-24T03:48:44Z |
| format | Article |
| id | doaj.art-65b79db8541545acaf475a8dd11c2572 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-24T03:48:44Z |
| publishDate | 2021-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-65b79db8541545acaf475a8dd11c25722022-12-21T17:16:39ZengElsevieriScience2589-00422021-10-012410103204Sleep-wake dynamics pre- and post-exposure to chronic social stressBasma Radwan0Gloria Jansen1Dipesh Chaudhury2Department of Biology, New York University Abu Dhabi, Abu Dhabi, United Arab EmiratesWellcome Trust Developmental Mechanisms, Cambridge University, Cambridge, UKDepartment of Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates; Corresponding authorSummary: An analytical approach combining the statistical distributions of the sleep-wake bouts and the Markov transition matrix is used to explain the under-examined association between the microarchitecture of the sleep-wake cycle and susceptibility to chronic social stress in C57BL/6J mice. We separated the sleep-wake transitions into distinct sleep-wake sequences, NREM↔Wake and NREM→REM→Wake, which are controlled by independent neural circuits. Our findings imply greater pull toward the wake leading to early termination and fragmentation of the sleep bouts in the light in both sleep-wake sequences pre- and post-stress. Moreover, the stability of NREM in the NREM↔Wake transition was lower, and the probability of transitioning to wake was higher in susceptible relative to resilient or stress-naïve mice pre- and post-stress. Our findings help elucidate the mechanistic interplay between sleep and mood by suggesting the potential neural underpinnings of sleep disturbances responsible the aberrant transitions of sleep-wake bouts exhibited by the stress-susceptible phenotype.http://www.sciencedirect.com/science/article/pii/S258900422101172Xbehavioral neurosciencesystems neuroscience |
| spellingShingle | Basma Radwan Gloria Jansen Dipesh Chaudhury Sleep-wake dynamics pre- and post-exposure to chronic social stress iScience behavioral neuroscience systems neuroscience |
| title | Sleep-wake dynamics pre- and post-exposure to chronic social stress |
| title_full | Sleep-wake dynamics pre- and post-exposure to chronic social stress |
| title_fullStr | Sleep-wake dynamics pre- and post-exposure to chronic social stress |
| title_full_unstemmed | Sleep-wake dynamics pre- and post-exposure to chronic social stress |
| title_short | Sleep-wake dynamics pre- and post-exposure to chronic social stress |
| title_sort | sleep wake dynamics pre and post exposure to chronic social stress |
| topic | behavioral neuroscience systems neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S258900422101172X |
| work_keys_str_mv | AT basmaradwan sleepwakedynamicspreandpostexposuretochronicsocialstress AT gloriajansen sleepwakedynamicspreandpostexposuretochronicsocialstress AT dipeshchaudhury sleepwakedynamicspreandpostexposuretochronicsocialstress |