Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios
Apatite is widely used in medicine as a biomaterial for bone tissue restoration. Properties of apatite depend on its composition, including the Ca/P ratio. This paper shows what range of Ca/P ratio can be attained in apatite by the mechanochemical method of synthesis, providing fast formation of a s...
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MDPI AG
2022-08-01
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| Series: | Ceramics |
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| Online Access: | https://www.mdpi.com/2571-6131/5/3/31 |
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| author | Marina V. Chaikina Natalia V. Bulina Olga B. Vinokurova Konstantin B. Gerasimov Igor Yu. Prosanov Nikolay B. Kompankov Olga B. Lapina Evgeniy S. Papulovskiy Arcady V. Ishchenko Svetlana V. Makarova |
| author_facet | Marina V. Chaikina Natalia V. Bulina Olga B. Vinokurova Konstantin B. Gerasimov Igor Yu. Prosanov Nikolay B. Kompankov Olga B. Lapina Evgeniy S. Papulovskiy Arcady V. Ishchenko Svetlana V. Makarova |
| author_sort | Marina V. Chaikina |
| collection | DOAJ |
| description | Apatite is widely used in medicine as a biomaterial for bone tissue restoration. Properties of apatite depend on its composition, including the Ca/P ratio. This paper shows what range of Ca/P ratio can be attained in apatite by the mechanochemical method of synthesis, providing fast formation of a single-phase product. The synthesis was carried out from a reaction mixture of CaHPO<sub>4</sub> and CaO at different Ca/P ratios in the range of 1.17–2.10. The products were studied by PXRD, FTIR and NMR spectroscopy, HRTEM, and STA. In mixtures with a low initial Ca/P ratio (1.17–1.48), directly in the mill, the formation of calcium orthophosphate with whitlockite structure containing an HPO<sub>4</sub><sup>2−</sup> group and structural water is shown for the first time. This phosphate has structure similar to that of whitlockites of hydrothermal origin and differs from high-temperature β-tricalcium phosphate that has composition Ca<sub>3</sub>(PO<sub>4</sub>)<sub>3</sub>. A series of samples of apatite was obtained with varied composition, which depends on the initial Ca/P ratio. At Ca/P < 1.67, the formation of two types of calcium-deficient apatite was documented. At Ca/P > 1.67, the existence of two types of calcium-rich apatite is confirmed. |
| first_indexed | 2024-03-10T00:25:42Z |
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| issn | 2571-6131 |
| language | English |
| last_indexed | 2024-03-10T00:25:42Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Ceramics |
| spelling | doaj.art-65ba1bac624642d6bf7e6f7f192df2022023-11-23T15:34:47ZengMDPI AGCeramics2571-61312022-08-015340442210.3390/ceramics5030031Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P RatiosMarina V. Chaikina0Natalia V. Bulina1Olga B. Vinokurova2Konstantin B. Gerasimov3Igor Yu. Prosanov4Nikolay B. Kompankov5Olga B. Lapina6Evgeniy S. Papulovskiy7Arcady V. Ishchenko8Svetlana V. Makarova9Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaInstitute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaInstitute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaInstitute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaInstitute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaA.V. Nikolaev Institute of Inorganic Chemistry, Siberian Branch of Russian Academy of Sciences, Lavrentyev Ave. 3, 630090 Novosibirsk, RussiaG.K. Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, Pr. Akad. Lavrentieva 5, 630090 Novosibirsk, RussiaG.K. Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, Pr. Akad. Lavrentieva 5, 630090 Novosibirsk, RussiaG.K. Boreskov Institute of Catalysis, Siberian Branch of Russian Academy of Sciences, Pr. Akad. Lavrentieva 5, 630090 Novosibirsk, RussiaInstitute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Kutateladze Str. 18, 630128 Novosibirsk, RussiaApatite is widely used in medicine as a biomaterial for bone tissue restoration. Properties of apatite depend on its composition, including the Ca/P ratio. This paper shows what range of Ca/P ratio can be attained in apatite by the mechanochemical method of synthesis, providing fast formation of a single-phase product. The synthesis was carried out from a reaction mixture of CaHPO<sub>4</sub> and CaO at different Ca/P ratios in the range of 1.17–2.10. The products were studied by PXRD, FTIR and NMR spectroscopy, HRTEM, and STA. In mixtures with a low initial Ca/P ratio (1.17–1.48), directly in the mill, the formation of calcium orthophosphate with whitlockite structure containing an HPO<sub>4</sub><sup>2−</sup> group and structural water is shown for the first time. This phosphate has structure similar to that of whitlockites of hydrothermal origin and differs from high-temperature β-tricalcium phosphate that has composition Ca<sub>3</sub>(PO<sub>4</sub>)<sub>3</sub>. A series of samples of apatite was obtained with varied composition, which depends on the initial Ca/P ratio. At Ca/P < 1.67, the formation of two types of calcium-deficient apatite was documented. At Ca/P > 1.67, the existence of two types of calcium-rich apatite is confirmed.https://www.mdpi.com/2571-6131/5/3/31bioceramicscalcium phosphateshydroxyapatitecalcium-deficient apatitecalcium-rich apatitetricalcium phosphate |
| spellingShingle | Marina V. Chaikina Natalia V. Bulina Olga B. Vinokurova Konstantin B. Gerasimov Igor Yu. Prosanov Nikolay B. Kompankov Olga B. Lapina Evgeniy S. Papulovskiy Arcady V. Ishchenko Svetlana V. Makarova Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios Ceramics bioceramics calcium phosphates hydroxyapatite calcium-deficient apatite calcium-rich apatite tricalcium phosphate |
| title | Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios |
| title_full | Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios |
| title_fullStr | Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios |
| title_full_unstemmed | Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios |
| title_short | Possibilities of Mechanochemical Synthesis of Apatites with Different Ca/P Ratios |
| title_sort | possibilities of mechanochemical synthesis of apatites with different ca p ratios |
| topic | bioceramics calcium phosphates hydroxyapatite calcium-deficient apatite calcium-rich apatite tricalcium phosphate |
| url | https://www.mdpi.com/2571-6131/5/3/31 |
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