Coronavirus disease 2019: Morphological changes in peripheral blood cells
INTRODUCTION: The impact of severe acute respiratory syndrome coronavirus 2 on global health has been considerable since its emergence. Clinical laboratories are crucial in the diagnosis, treatment, and prognosis of patients with coronavirus disease 2019 (COVID-19). The study aims to review the pub...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Iraqi Journal of Hematology |
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| Online Access: | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=1;spage=1;epage=7;aulast=Alamin |
| _version_ | 1797774156398329856 |
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| author | Amin A Alamin |
| author_facet | Amin A Alamin |
| author_sort | Amin A Alamin |
| collection | DOAJ |
| description | INTRODUCTION: The impact of severe acute respiratory syndrome coronavirus 2 on global health has been considerable since its emergence. Clinical laboratories are crucial in the diagnosis, treatment, and prognosis of patients with coronavirus disease 2019 (COVID-19). The study aims to review the published literature on the abnormal morphological features found in the peripheral blood smears of patients with COVID-19.
MATERIALS AND METHODS: A nonsystematic narrative review was carried out, utilizing four databases to search for publications that presented qualitative alterations in the peripheral blood cells of individuals with COVID-19. Thirty-three studies published between January 2020 and July 2022 were ultimately included in the review.
RESULTS: The majority of the studies reviewed focused on qualitative changes, with peripheral blood cell shape identified as an indicator of post-COVID-19 syndrome severity. Plasmacytic cells were found to be a relatively specific marker for COVID-19, while fragmented neutrophils were identified as an extremely sensitive morphological marker. Activation of monocytes was a strong predictor of disease outcome, and platelet aggregates served as an indicator of disease progression.
CONCLUSIONS: The identification of morphological abnormalities in peripheral blood cells can aid in diagnosing and prognosticating COVID-19 patients. Daily complete blood count tests in hospitalized patients are crucial for identifying numerical and morphological irregularities that indicate poor clinical outcomes and disease progression. |
| first_indexed | 2024-03-12T22:15:54Z |
| format | Article |
| id | doaj.art-65bacac167bd46c3b94e5e85f59d1a1c |
| institution | Directory Open Access Journal |
| issn | 2072-8069 |
| language | English |
| last_indexed | 2024-03-12T22:15:54Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Iraqi Journal of Hematology |
| spelling | doaj.art-65bacac167bd46c3b94e5e85f59d1a1c2023-07-23T11:17:34ZengWolters Kluwer Medknow PublicationsIraqi Journal of Hematology2072-80692023-01-011211710.4103/ijh.ijh_30_23Coronavirus disease 2019: Morphological changes in peripheral blood cellsAmin A AlaminINTRODUCTION: The impact of severe acute respiratory syndrome coronavirus 2 on global health has been considerable since its emergence. Clinical laboratories are crucial in the diagnosis, treatment, and prognosis of patients with coronavirus disease 2019 (COVID-19). The study aims to review the published literature on the abnormal morphological features found in the peripheral blood smears of patients with COVID-19. MATERIALS AND METHODS: A nonsystematic narrative review was carried out, utilizing four databases to search for publications that presented qualitative alterations in the peripheral blood cells of individuals with COVID-19. Thirty-three studies published between January 2020 and July 2022 were ultimately included in the review. RESULTS: The majority of the studies reviewed focused on qualitative changes, with peripheral blood cell shape identified as an indicator of post-COVID-19 syndrome severity. Plasmacytic cells were found to be a relatively specific marker for COVID-19, while fragmented neutrophils were identified as an extremely sensitive morphological marker. Activation of monocytes was a strong predictor of disease outcome, and platelet aggregates served as an indicator of disease progression. CONCLUSIONS: The identification of morphological abnormalities in peripheral blood cells can aid in diagnosing and prognosticating COVID-19 patients. Daily complete blood count tests in hospitalized patients are crucial for identifying numerical and morphological irregularities that indicate poor clinical outcomes and disease progression.http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=1;spage=1;epage=7;aulast=Alaminblood smearcoronavirus disease 2019morphologyperipheral blood cellssevere acute respiratory syndrome coronavirus 2 |
| spellingShingle | Amin A Alamin Coronavirus disease 2019: Morphological changes in peripheral blood cells Iraqi Journal of Hematology blood smear coronavirus disease 2019 morphology peripheral blood cells severe acute respiratory syndrome coronavirus 2 |
| title | Coronavirus disease 2019: Morphological changes in peripheral blood cells |
| title_full | Coronavirus disease 2019: Morphological changes in peripheral blood cells |
| title_fullStr | Coronavirus disease 2019: Morphological changes in peripheral blood cells |
| title_full_unstemmed | Coronavirus disease 2019: Morphological changes in peripheral blood cells |
| title_short | Coronavirus disease 2019: Morphological changes in peripheral blood cells |
| title_sort | coronavirus disease 2019 morphological changes in peripheral blood cells |
| topic | blood smear coronavirus disease 2019 morphology peripheral blood cells severe acute respiratory syndrome coronavirus 2 |
| url | http://www.ijhonline.org/article.asp?issn=2072-8069;year=2023;volume=12;issue=1;spage=1;epage=7;aulast=Alamin |
| work_keys_str_mv | AT aminaalamin coronavirusdisease2019morphologicalchangesinperipheralbloodcells |