Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran
Background: Detection of hepatitis B virus (HBV) genomes without detectable hepatitis B surface antigen (HBs-Ag) is termed occult HBV infection (OHBV) that may be transmitted by blood transfusion or organ transplantation and has acute reactivation when an immunosuppressive status like human immunode...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=13;spage=64;epage=66;aulast=Khorvash |
| _version_ | 1819090759826014208 |
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| author | Farzin Khorvash Abbasali Javadi Katayoun Tayeri Behrooz Ataei |
| author_facet | Farzin Khorvash Abbasali Javadi Katayoun Tayeri Behrooz Ataei |
| author_sort | Farzin Khorvash |
| collection | DOAJ |
| description | Background: Detection of hepatitis B virus (HBV) genomes without detectable hepatitis B surface antigen (HBs-Ag) is termed occult HBV infection (OHBV) that may be transmitted by blood transfusion or organ transplantation and has acute reactivation when an immunosuppressive status like human immunodeficiency virus (HIV) infection occurs. We aimed to evaluate OHBV in HIV-infected patients with isolated antibodies to hepatitis B core antigen (anti-HBc) in Isfahan, Iran. Materials and Methods: In a cross-sectional study during August-September 2011, serum samples from HIV-infected patients who attended Isfahan Consultation Center for Behavioral Diseases were tested for HBs-Ag and anti-HBc using ELISA method. HBV-deoxyribonucleic acid (DNA) was detected and quantified in plasma of HBs-Ag negative/anti-HBc positive subjects by real-time polymerase chain reaction. Results: From 64 HIV-positive individuals, 12 (18%) patients were HBs-Ag negative/anti-HBc positive, and from those 3 (25%) had detectable HBV-DNA in their plasma. Conclusion: It seems that occult HBV might be assessed and be treated in HIV-infected patients. |
| first_indexed | 2024-12-21T22:28:56Z |
| format | Article |
| id | doaj.art-65bb2e1ffdc74fa9a1fbf2245a0fb4f5 |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-21T22:28:56Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-65bb2e1ffdc74fa9a1fbf2245a0fb4f52022-12-21T18:48:08ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362014-01-0119136466Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, IranFarzin KhorvashAbbasali JavadiKatayoun TayeriBehrooz AtaeiBackground: Detection of hepatitis B virus (HBV) genomes without detectable hepatitis B surface antigen (HBs-Ag) is termed occult HBV infection (OHBV) that may be transmitted by blood transfusion or organ transplantation and has acute reactivation when an immunosuppressive status like human immunodeficiency virus (HIV) infection occurs. We aimed to evaluate OHBV in HIV-infected patients with isolated antibodies to hepatitis B core antigen (anti-HBc) in Isfahan, Iran. Materials and Methods: In a cross-sectional study during August-September 2011, serum samples from HIV-infected patients who attended Isfahan Consultation Center for Behavioral Diseases were tested for HBs-Ag and anti-HBc using ELISA method. HBV-deoxyribonucleic acid (DNA) was detected and quantified in plasma of HBs-Ag negative/anti-HBc positive subjects by real-time polymerase chain reaction. Results: From 64 HIV-positive individuals, 12 (18%) patients were HBs-Ag negative/anti-HBc positive, and from those 3 (25%) had detectable HBV-DNA in their plasma. Conclusion: It seems that occult HBV might be assessed and be treated in HIV-infected patients.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=13;spage=64;epage=66;aulast=KhorvashHepatitis Bhepatitis B core antigenhuman immunodeficiency virus |
| spellingShingle | Farzin Khorvash Abbasali Javadi Katayoun Tayeri Behrooz Ataei Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran Journal of Research in Medical Sciences Hepatitis B hepatitis B core antigen human immunodeficiency virus |
| title | Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran |
| title_full | Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran |
| title_fullStr | Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran |
| title_full_unstemmed | Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran |
| title_short | Occult hepatitis B virus infection among human immunodeficiency virus-infected patients with isolated hepatitis B core antibody in Isfahan, Iran |
| title_sort | occult hepatitis b virus infection among human immunodeficiency virus infected patients with isolated hepatitis b core antibody in isfahan iran |
| topic | Hepatitis B hepatitis B core antigen human immunodeficiency virus |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2014;volume=19;issue=13;spage=64;epage=66;aulast=Khorvash |
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