Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy
Objective- To evaluate and compare kidney function with and without saffron administration and consider the diuretic and nephroprotective effects of aqueous extract of this substance in normal cats. Design- Descriptive study Animals- 6 female healthy cats (age: 2 to 4 years, average weight: 4 kg) -...
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| Format: | Article |
| Language: | English |
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Iranian Veterinary Surgery Association (IVSA)
2014-12-01
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| Series: | Iranian Journal of Veterinary Surgery |
| Subjects: | |
| Online Access: | http://www.ivsajournals.com/article_7764_797a4677163d10684d28b7ec880f49c0.pdf |
| _version_ | 1818930318626783232 |
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| author | Darioush Vosough Samira Hosseini Hooshyar Elahe Moini |
| author_facet | Darioush Vosough Samira Hosseini Hooshyar Elahe Moini |
| author_sort | Darioush Vosough |
| collection | DOAJ |
| description | Objective- To evaluate and compare kidney function with and without saffron administration and consider the diuretic and nephroprotective effects of aqueous extract of this substance in normal cats.
Design- Descriptive study
Animals- 6 female healthy cats (age: 2 to 4 years, average weight: 4 kg) - no clinical sign of renal disorders and prior to presentation
Procedures- The scintigraphy of right and left kidney was performed using Gamma camera (Piker Model) and 99mTc-DTPA as radiopharmaceutical with and without saffron administration. The average quantities of Total and individual GFR, Time to peak activity (TOP), Emptying half time and 3-min activity are the determined parameters in this evaluation.
Results- A significantly higher amount of total GFR was present at the end of the study with Saffron administration compared with control study with saline administration (P= 0.017). Also T1/2 of the treatment renograms was significantly shorter than that of the control renograms (P=0.002 for right kidney and p=0.001 for left kidney).
Conclusion and Clinical Relevance- Administration of saffron increased the glomerular filtration rate and shortened the emptying half-time of radiopharmaceutical. This study shows that Saffron as a harmless substance can play as a diuretic substance, therefore can play a significant role in the diagnosis and treatment of many diseases. |
| first_indexed | 2024-12-20T03:58:48Z |
| format | Article |
| id | doaj.art-65bbb039c62d414784162b2833eb8db2 |
| institution | Directory Open Access Journal |
| issn | 2008-3033 2008-3033 |
| language | English |
| last_indexed | 2024-12-20T03:58:48Z |
| publishDate | 2014-12-01 |
| publisher | Iranian Veterinary Surgery Association (IVSA) |
| record_format | Article |
| series | Iranian Journal of Veterinary Surgery |
| spelling | doaj.art-65bbb039c62d414784162b2833eb8db22022-12-21T19:54:13ZengIranian Veterinary Surgery Association (IVSA)Iranian Journal of Veterinary Surgery2008-30332008-30332014-12-0109245507764Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal ScintigraphyDarioush Vosough0Samira Hosseini Hooshyar1Elahe Moini2Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, IranResearch Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, IranPhD candidate of food hygiene and quality control, faculty of veterinary medicine, Shahrekord university, Shahrekord, IranObjective- To evaluate and compare kidney function with and without saffron administration and consider the diuretic and nephroprotective effects of aqueous extract of this substance in normal cats. Design- Descriptive study Animals- 6 female healthy cats (age: 2 to 4 years, average weight: 4 kg) - no clinical sign of renal disorders and prior to presentation Procedures- The scintigraphy of right and left kidney was performed using Gamma camera (Piker Model) and 99mTc-DTPA as radiopharmaceutical with and without saffron administration. The average quantities of Total and individual GFR, Time to peak activity (TOP), Emptying half time and 3-min activity are the determined parameters in this evaluation. Results- A significantly higher amount of total GFR was present at the end of the study with Saffron administration compared with control study with saline administration (P= 0.017). Also T1/2 of the treatment renograms was significantly shorter than that of the control renograms (P=0.002 for right kidney and p=0.001 for left kidney). Conclusion and Clinical Relevance- Administration of saffron increased the glomerular filtration rate and shortened the emptying half-time of radiopharmaceutical. This study shows that Saffron as a harmless substance can play as a diuretic substance, therefore can play a significant role in the diagnosis and treatment of many diseases.http://www.ivsajournals.com/article_7764_797a4677163d10684d28b7ec880f49c0.pdfSaffronKidneyscintigraphy99mTc-DTPACat |
| spellingShingle | Darioush Vosough Samira Hosseini Hooshyar Elahe Moini Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy Iranian Journal of Veterinary Surgery Saffron Kidney scintigraphy 99mTc-DTPA Cat |
| title | Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy |
| title_full | Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy |
| title_fullStr | Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy |
| title_full_unstemmed | Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy |
| title_short | Effect of Saffron (Crocus Sativus) Administration on Kidney Function in Normal Cats as Determined by Use of 99mTc-DTPA Renal Scintigraphy |
| title_sort | effect of saffron crocus sativus administration on kidney function in normal cats as determined by use of 99mtc dtpa renal scintigraphy |
| topic | Saffron Kidney scintigraphy 99mTc-DTPA Cat |
| url | http://www.ivsajournals.com/article_7764_797a4677163d10684d28b7ec880f49c0.pdf |
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