Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters
Background: Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation. OBJECTIVES: The aim of thi...
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| Format: | Article |
| Language: | English |
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University of Tehran
2019-06-01
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| Series: | Iranian Journal of Veterinary Medicine |
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| Online Access: | https://ijvm.ut.ac.ir/article_71291_191a5af85af75236d3275d718a2a8c56.pdf |
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| author | Majid Zakerian Reza Avizeh Alireza Ghadiri Mohammad Razi Jalali Mahdi Pourmahdi Hosein Najafzadeh |
| author_facet | Majid Zakerian Reza Avizeh Alireza Ghadiri Mohammad Razi Jalali Mahdi Pourmahdi Hosein Najafzadeh |
| author_sort | Majid Zakerian |
| collection | DOAJ |
| description | Background: Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation. OBJECTIVES: The aim of this study was to evaluate the safety of senna as an alternative or adjunct to polyethylene glycol solution in dogs using hematology and biochemistry. METHODS: For this purpose, 20 mongrel dogs were randomly allocated to receive 1 of 4 different bowel preparation regimens including PEG, senna or their combinations plus enema. Serum concentrations of sodium, potassium, total calcium, phosphorus, chloride, magnesium, PCV, total protein, ALT, AST, BUN and creatinine were measured at 0, 1, 2, 5, 6 and 24 hours after the first ingestion of laxative solutions. RESULTS: Statistical analysis showed that PEG or senna solutions had no significant effect on serum concentration of the evaluated parameters (P>0.05). Despite the significant changes in serum concentration of all measured parameters based on time of sampling in all groups, they were in their normal ranges (P>0.05). CONCLUSIONS: This is the first evaluation of the safety of bowel preparation with senna in dogs. This study showed that the use of PEG and senna for colon cleansing in dogs did not have any deleterious effects on their serum biochemical and electrolytes concentration. |
| first_indexed | 2024-12-20T00:25:30Z |
| format | Article |
| id | doaj.art-65c2189927e24f16b11de6a9708e8eae |
| institution | Directory Open Access Journal |
| issn | 2251-8894 2252-0554 |
| language | English |
| last_indexed | 2024-12-20T00:25:30Z |
| publishDate | 2019-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Iranian Journal of Veterinary Medicine |
| spelling | doaj.art-65c2189927e24f16b11de6a9708e8eae2022-12-21T20:00:04ZengUniversity of TehranIranian Journal of Veterinary Medicine2251-88942252-05542019-06-0113217518510.22059/ijvm.2019.259726.100490171291Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical ParametersMajid Zakerian0Reza Avizeh1Alireza Ghadiri2Mohammad Razi Jalali3Mahdi Pourmahdi4Hosein Najafzadeh5MVSc Graduated of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz. Ahvaz, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,IranDepartment of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, IranBackground: Colonoscopy is the preferred procedure for diagnosis of large-bowel diseases in dogs. Polyethylene glycol (PEG) is the most commonly used laxative for colonic cleansing. Senna has been used in traditional medicine as a laxative and an aid to treat constipation. OBJECTIVES: The aim of this study was to evaluate the safety of senna as an alternative or adjunct to polyethylene glycol solution in dogs using hematology and biochemistry. METHODS: For this purpose, 20 mongrel dogs were randomly allocated to receive 1 of 4 different bowel preparation regimens including PEG, senna or their combinations plus enema. Serum concentrations of sodium, potassium, total calcium, phosphorus, chloride, magnesium, PCV, total protein, ALT, AST, BUN and creatinine were measured at 0, 1, 2, 5, 6 and 24 hours after the first ingestion of laxative solutions. RESULTS: Statistical analysis showed that PEG or senna solutions had no significant effect on serum concentration of the evaluated parameters (P>0.05). Despite the significant changes in serum concentration of all measured parameters based on time of sampling in all groups, they were in their normal ranges (P>0.05). CONCLUSIONS: This is the first evaluation of the safety of bowel preparation with senna in dogs. This study showed that the use of PEG and senna for colon cleansing in dogs did not have any deleterious effects on their serum biochemical and electrolytes concentration.https://ijvm.ut.ac.ir/article_71291_191a5af85af75236d3275d718a2a8c56.pdfcolonoscopydoglaxativepolyethylene glycolsenna |
| spellingShingle | Majid Zakerian Reza Avizeh Alireza Ghadiri Mohammad Razi Jalali Mahdi Pourmahdi Hosein Najafzadeh Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters Iranian Journal of Veterinary Medicine colonoscopy dog laxative polyethylene glycol senna |
| title | Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters |
| title_full | Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters |
| title_fullStr | Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters |
| title_full_unstemmed | Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters |
| title_short | Effect of Polyethylene Glycol and Senna Bowel Preparation in Dogs on Some Hematological and Serum Biochemical Parameters |
| title_sort | effect of polyethylene glycol and senna bowel preparation in dogs on some hematological and serum biochemical parameters |
| topic | colonoscopy dog laxative polyethylene glycol senna |
| url | https://ijvm.ut.ac.ir/article_71291_191a5af85af75236d3275d718a2a8c56.pdf |
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