Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial
Aim: The aim of this study is to evaluate the efficacy of 1% curcumin (CU) solution and compare it with conventional irrigant i.e., 0.2% chlorhexidine (CHX) gluconate and a positive control (saline) as an adjunct to thorough scaling and root planing. Materials and Methods: A total of 23 patients wit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Contemporary Clinical Dentistry |
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| Online Access: | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2013;volume=4;issue=2;spage=186;epage=191;aulast=Gottumukkala |
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| author | Sruthima N. V. S. Gottumukkala Suneetha Koneru Satheesh Mannem Narendra Mandalapu |
| author_facet | Sruthima N. V. S. Gottumukkala Suneetha Koneru Satheesh Mannem Narendra Mandalapu |
| author_sort | Sruthima N. V. S. Gottumukkala |
| collection | DOAJ |
| description | Aim: The aim of this study is to evaluate the efficacy of 1% curcumin (CU) solution and compare it with conventional irrigant i.e., 0.2% chlorhexidine (CHX) gluconate and a positive control (saline) as an adjunct to thorough scaling and root planing. Materials and Methods: A total of 23 patients with non-adjacent probing pocket depths (PPDs) ≥5mm were randomly assigned to CHX, CU and positive control irrigation groups and subjected to randomized single blinded clinical control trial. The clinical parameters bleeding on probing, redness, plaque index, PPD and microbiological parameter N-benzoyl-DL-arginine-2-naphthylamide (BANA) test were evaluated at baseline, 1, 3 and 6 months interval. Results: At 1 month evaluation, CU group showed better results compared with the other groups. However, by the end of the study period CHX group showed the best results with as light recurrence in the CU group. The results of BANA test showed similar results for both CU and CHX group throughout the study period. Conclusion: The results of this study show a mild to moderate beneficiary effect of CU irrigation when used as an adjunct to Scaling and root planing. Further studies may be required using varied concentrations of the drug to improve the substantivity of the drug and also to prevent early re-colonization of periodontal pathogens. |
| first_indexed | 2024-12-11T17:51:52Z |
| format | Article |
| id | doaj.art-65c307ce90984e0aabee2e48b26c6846 |
| institution | Directory Open Access Journal |
| issn | 0976-237X 0976-2361 |
| language | English |
| last_indexed | 2024-12-11T17:51:52Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Contemporary Clinical Dentistry |
| spelling | doaj.art-65c307ce90984e0aabee2e48b26c68462022-12-22T00:56:12ZengWolters Kluwer Medknow PublicationsContemporary Clinical Dentistry0976-237X0976-23612013-01-014218619110.4103/0976-237X.114874Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trialSruthima N. V. S. GottumukkalaSuneetha KoneruSatheesh MannemNarendra MandalapuAim: The aim of this study is to evaluate the efficacy of 1% curcumin (CU) solution and compare it with conventional irrigant i.e., 0.2% chlorhexidine (CHX) gluconate and a positive control (saline) as an adjunct to thorough scaling and root planing. Materials and Methods: A total of 23 patients with non-adjacent probing pocket depths (PPDs) ≥5mm were randomly assigned to CHX, CU and positive control irrigation groups and subjected to randomized single blinded clinical control trial. The clinical parameters bleeding on probing, redness, plaque index, PPD and microbiological parameter N-benzoyl-DL-arginine-2-naphthylamide (BANA) test were evaluated at baseline, 1, 3 and 6 months interval. Results: At 1 month evaluation, CU group showed better results compared with the other groups. However, by the end of the study period CHX group showed the best results with as light recurrence in the CU group. The results of BANA test showed similar results for both CU and CHX group throughout the study period. Conclusion: The results of this study show a mild to moderate beneficiary effect of CU irrigation when used as an adjunct to Scaling and root planing. Further studies may be required using varied concentrations of the drug to improve the substantivity of the drug and also to prevent early re-colonization of periodontal pathogens.http://www.contempclindent.org/article.asp?issn=0976-237X;year=2013;volume=4;issue=2;spage=186;epage=191;aulast=GottumukkalaCurcuminchlorhexidine digluconatechronic periodontitisirrigationperiodontal pocket |
| spellingShingle | Sruthima N. V. S. Gottumukkala Suneetha Koneru Satheesh Mannem Narendra Mandalapu Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial Contemporary Clinical Dentistry Curcumin chlorhexidine digluconate chronic periodontitis irrigation periodontal pocket |
| title | Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial |
| title_full | Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial |
| title_fullStr | Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial |
| title_full_unstemmed | Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial |
| title_short | Effectiveness of sub gingival irrigation of an indigenous 1% curcumin solution on clinical and microbiological parameters in chronic periodontitis patients: A pilot randomized clinical trial |
| title_sort | effectiveness of sub gingival irrigation of an indigenous 1 curcumin solution on clinical and microbiological parameters in chronic periodontitis patients a pilot randomized clinical trial |
| topic | Curcumin chlorhexidine digluconate chronic periodontitis irrigation periodontal pocket |
| url | http://www.contempclindent.org/article.asp?issn=0976-237X;year=2013;volume=4;issue=2;spage=186;epage=191;aulast=Gottumukkala |
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