Inflammasomes: Mechanisms of Action and Involvement in Human Diseases
Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1766 |
| _version_ | 1797591970526265344 |
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| author | Dimitri Bulté Chiara Rigamonti Alessandro Romano Alessandra Mortellaro |
| author_facet | Dimitri Bulté Chiara Rigamonti Alessandro Romano Alessandra Mortellaro |
| author_sort | Dimitri Bulté |
| collection | DOAJ |
| description | Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mechanisms has greatly progressed. We therefore provide an up-to-date overview of the various inflammasomes and their known mechanisms of action. In addition, we highlight the involvement of various inflammasomes and their pathogenic mechanisms in common autoinflammatory, autoimmune and neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We conclude by speculating on the future avenues of research needed to better understand the roles of inflammasomes in health and disease. |
| first_indexed | 2024-03-11T01:45:10Z |
| format | Article |
| id | doaj.art-65c35785acde4cf4b825b5e5fbda1df3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:10Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-65c35785acde4cf4b825b5e5fbda1df32023-11-18T16:19:44ZengMDPI AGCells2073-44092023-07-011213176610.3390/cells12131766Inflammasomes: Mechanisms of Action and Involvement in Human DiseasesDimitri Bulté0Chiara Rigamonti1Alessandro Romano2Alessandra Mortellaro3San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalySan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalySan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalySan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, ItalyInflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response and inflammation at the post-translational level. Yet despite their protective role, aberrant activation of inflammasome proteins and gain of function mutations in inflammasome component genes seem to contribute to the development and progression of human autoimmune and autoinflammatory diseases. In the past decade, our understanding of inflammasome biology and activation mechanisms has greatly progressed. We therefore provide an up-to-date overview of the various inflammasomes and their known mechanisms of action. In addition, we highlight the involvement of various inflammasomes and their pathogenic mechanisms in common autoinflammatory, autoimmune and neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. We conclude by speculating on the future avenues of research needed to better understand the roles of inflammasomes in health and disease.https://www.mdpi.com/2073-4409/12/13/1766inflammasomeinterleukin 1pyroptosisautoinflammatoryautoimmuneneuroinflammatory and neurogenerative disorders |
| spellingShingle | Dimitri Bulté Chiara Rigamonti Alessandro Romano Alessandra Mortellaro Inflammasomes: Mechanisms of Action and Involvement in Human Diseases Cells inflammasome interleukin 1 pyroptosis autoinflammatory autoimmune neuroinflammatory and neurogenerative disorders |
| title | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
| title_full | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
| title_fullStr | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
| title_full_unstemmed | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
| title_short | Inflammasomes: Mechanisms of Action and Involvement in Human Diseases |
| title_sort | inflammasomes mechanisms of action and involvement in human diseases |
| topic | inflammasome interleukin 1 pyroptosis autoinflammatory autoimmune neuroinflammatory and neurogenerative disorders |
| url | https://www.mdpi.com/2073-4409/12/13/1766 |
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