CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells
Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00061-1 |
| _version_ | 1818399458918924288 |
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| author | Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed |
| author_facet | Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed |
| author_sort | Arnaud P. J. Giese |
| collection | DOAJ |
| description | Inner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice. |
| first_indexed | 2024-12-14T07:21:00Z |
| format | Article |
| id | doaj.art-65c3629626804bdea9661937eb27fcb2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:21:00Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-65c3629626804bdea9661937eb27fcb22022-12-21T23:11:37ZengNature PortfolioNature Communications2041-17232017-06-018111310.1038/s41467-017-00061-1CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cellsArnaud P. J. Giese0Yi-Quan Tang1Ghanshyam P. Sinha2Michael R. Bowl3Adam C. Goldring4Andrew Parker5Mary J. Freeman6Steve D. M. Brown7Saima Riazuddin8Robert Fettiplace9William R. Schafer10Gregory I. Frolenkov11Zubair M. Ahmed12Department of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of MarylandDivision of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusDepartment of Physiology, College of Medicine, University of KentuckyMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusDepartment of Neuroscience, School of Medicine, University of WisconsinMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusDepartment of Physiology, College of Medicine, University of KentuckyMRC Harwell Institute, Mammalian Genetics Unit, Harwell CampusDepartment of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of MarylandDepartment of Neuroscience, School of Medicine, University of WisconsinDivision of Neurobiology, MRC Laboratory of Molecular Biology, Cambridge Biomedical CampusDepartment of Physiology, College of Medicine, University of KentuckyDepartment of Otorhinolaryngology Head & Neck Surgery, School of Medicine, University of MarylandInner ear hair cells detect sound through deflection of stereocilia that harbor mechanically-gated channels. Here the authors show that protein responsible for Usher syndrome, CIB2, interacts with these channels and is essential for their function and hearing in mice.https://doi.org/10.1038/s41467-017-00061-1 |
| spellingShingle | Arnaud P. J. Giese Yi-Quan Tang Ghanshyam P. Sinha Michael R. Bowl Adam C. Goldring Andrew Parker Mary J. Freeman Steve D. M. Brown Saima Riazuddin Robert Fettiplace William R. Schafer Gregory I. Frolenkov Zubair M. Ahmed CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells Nature Communications |
| title | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
| title_full | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
| title_fullStr | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
| title_full_unstemmed | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
| title_short | CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells |
| title_sort | cib2 interacts with tmc1 and tmc2 and is essential for mechanotransduction in auditory hair cells |
| url | https://doi.org/10.1038/s41467-017-00061-1 |
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