Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration
Surgical repair of groin protrusions is one of the most frequently performed procedures. Currently, open or laparoscopic repair of inguinal hernias with flat meshes deployed over the hernial defect is considered the gold standard. However, fixation of the implant, poor quality biologic response to m...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/3/434 |
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| author | Giuseppe Amato Roberto Puleio Giorgio Romano Pietro Giorgio Calò Giuseppe Di Buono Luca Cicero Giovanni Cassata Thorsten Goetze Salvatore Buscemi Antonino Agrusa Vito Rodolico |
| author_facet | Giuseppe Amato Roberto Puleio Giorgio Romano Pietro Giorgio Calò Giuseppe Di Buono Luca Cicero Giovanni Cassata Thorsten Goetze Salvatore Buscemi Antonino Agrusa Vito Rodolico |
| author_sort | Giuseppe Amato |
| collection | DOAJ |
| description | Surgical repair of groin protrusions is one of the most frequently performed procedures. Currently, open or laparoscopic repair of inguinal hernias with flat meshes deployed over the hernial defect is considered the gold standard. However, fixation of the implant, poor quality biologic response to meshes and defective management of the defect represent sources of continuous debates. To overcome these issues, a different treatment concept has recently been proposed. It is based on a 3D scaffold named ProFlor, a flower shaped multilamellar device compressible on all planes. This 3D device is introduced into the hernial opening and, thanks to its inherent centrifugal expansion, permanently obliterates the defect in fixation-free fashion. While being made of the same polypropylene material as conventional hernia implants, the 3D design of ProFlor confers a proprietary dynamic responsivity, which unlike the foreign body reaction of flat/static meshes, promotes a true regenerative response. A long series of scientific evidence confirms that, moving in compliance with the physiologic cyclical load of the groin, ProFlor attracts tissue growth factors inducing the development of newly formed muscular, vascular and nervous structures, thus re-establishing the inguinal barrier formerly wasted by hernia disease. The development up to complete maturation of these highly specialized tissue elements was followed thanks to biopsies excised from ProFlor from the short-term up to years post implantation. Immunohistochemistry made it possible to document the concurrence of specific growth factors in the regenerative phenomena. The results achieved with ProFlor likely demonstrate that modifying the two-dimensional design of hernia meshes into a 3D outline and arranging the device to respond to kinetic stresses turns a conventional regressive foreign body response into advanced probiotic tissue regeneration. |
| first_indexed | 2024-03-11T06:54:30Z |
| format | Article |
| id | doaj.art-65c502f8d49d429c853258bae9aaf098 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T06:54:30Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-65c502f8d49d429c853258bae9aaf0982023-11-17T09:42:09ZengMDPI AGBiology2079-77372023-03-0112343410.3390/biology12030434Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue RegenerationGiuseppe Amato0Roberto Puleio1Giorgio Romano2Pietro Giorgio Calò3Giuseppe Di Buono4Luca Cicero5Giovanni Cassata6Thorsten Goetze7Salvatore Buscemi8Antonino Agrusa9Vito Rodolico10Department of Surgical, Oncological and Oral Sciences University of Palermo, 90127 Palermo, ItalyDepartment of Pathologic Anatomy and Histology, IZSS, 90129 Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences University of Palermo, 90127 Palermo, ItalyDepartment of Surgical Sciences, University of Cagliari, 09123 Cagliari, ItalyDepartment of Surgical, Oncological and Oral Sciences University of Palermo, 90127 Palermo, ItalyCEMERIT-IZSS, 90129 Palermo, ItalyCEMERIT-IZSS, 90129 Palermo, ItalyInstitut für Klinisch-Onkologische Forschung Krankenhaus Nordwest, 60488 Frankfurt/Main, GermanyDepartment of Surgical, Oncological and Oral Sciences University of Palermo, 90127 Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences University of Palermo, 90127 Palermo, ItalyDepartment PROMISE, Section Pathological Anatomy University of Palermo, 90127 Palermo, ItalySurgical repair of groin protrusions is one of the most frequently performed procedures. Currently, open or laparoscopic repair of inguinal hernias with flat meshes deployed over the hernial defect is considered the gold standard. However, fixation of the implant, poor quality biologic response to meshes and defective management of the defect represent sources of continuous debates. To overcome these issues, a different treatment concept has recently been proposed. It is based on a 3D scaffold named ProFlor, a flower shaped multilamellar device compressible on all planes. This 3D device is introduced into the hernial opening and, thanks to its inherent centrifugal expansion, permanently obliterates the defect in fixation-free fashion. While being made of the same polypropylene material as conventional hernia implants, the 3D design of ProFlor confers a proprietary dynamic responsivity, which unlike the foreign body reaction of flat/static meshes, promotes a true regenerative response. A long series of scientific evidence confirms that, moving in compliance with the physiologic cyclical load of the groin, ProFlor attracts tissue growth factors inducing the development of newly formed muscular, vascular and nervous structures, thus re-establishing the inguinal barrier formerly wasted by hernia disease. The development up to complete maturation of these highly specialized tissue elements was followed thanks to biopsies excised from ProFlor from the short-term up to years post implantation. Immunohistochemistry made it possible to document the concurrence of specific growth factors in the regenerative phenomena. The results achieved with ProFlor likely demonstrate that modifying the two-dimensional design of hernia meshes into a 3D outline and arranging the device to respond to kinetic stresses turns a conventional regressive foreign body response into advanced probiotic tissue regeneration.https://www.mdpi.com/2079-7737/12/3/434arteriesinguinal protrusion diseasemusclemuscle growth factorsneo-angiogenesisneo-myogenesis |
| spellingShingle | Giuseppe Amato Roberto Puleio Giorgio Romano Pietro Giorgio Calò Giuseppe Di Buono Luca Cicero Giovanni Cassata Thorsten Goetze Salvatore Buscemi Antonino Agrusa Vito Rodolico Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration Biology arteries inguinal protrusion disease muscle muscle growth factors neo-angiogenesis neo-myogenesis |
| title | Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration |
| title_full | Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration |
| title_fullStr | Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration |
| title_full_unstemmed | Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration |
| title_short | Physiologic Cyclical Load on Inguinal Hernia Scaffold ProFlor Turns Biological Response into Tissue Regeneration |
| title_sort | physiologic cyclical load on inguinal hernia scaffold proflor turns biological response into tissue regeneration |
| topic | arteries inguinal protrusion disease muscle muscle growth factors neo-angiogenesis neo-myogenesis |
| url | https://www.mdpi.com/2079-7737/12/3/434 |
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