Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia

Lysine-Specific Demethylase 1A as a Promising Target in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy characterized by the accumulation of incompletely differentiated progenitor cells (blasts) in the bone marrow and blood, and by suppression of normal hematopoiesis. It has recently become apparent that the AML genome is charact...

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Bibliographic Details
Main Authors: Daniela Magliulo, Rosa Bernardi, Samantha Messina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
LSD1
epigenetics
leukemia stem cells
acute myeloid leukemia
LSD1 inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00255/full

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