Suppressing the PI3K/AKT Pathway by miR-30d-5p Mimic Sensitizes Ovarian Cancer Cells to Cell Death Induced by High-Dose Estrogen

Suppressing the PI3K/AKT Pathway by miR-30d-5p Mimic Sensitizes Ovarian Cancer Cells to Cell Death Induced by High-Dose Estrogen

MicroRNAs are short non-coding RNA molecules that are involved in tumor development and are considered to be promising candidates in cancer therapy. Here, we studied the role of miR-30s in the pathophysiology of ovarian cancer. According to our results miR-30a-5p, miR-30d-5p, and miR-30e-5p were ove...

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Bibliographic Details
Main Authors: Alexandra Varga, Éva Márton, Arnold Markovics, András Penyige, István Balogh, Bálint Nagy, Melinda Szilágyi
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
miR-30
ovarian cancer
estrogen receptor
high-dose estrogen
cell proliferation
cell death
Online Access:https://www.mdpi.com/2227-9059/10/9/2060

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