Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans
Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stere...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-10-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/10/10/2300 |
| _version_ | 1818015699315982336 |
|---|---|
| author | Richard Lutz Eileen White Paul Falkowski Costantino Vetriani Richard Rosario-Passapera Liti Haramaty Eric H. Andrianasolo |
| author_facet | Richard Lutz Eileen White Paul Falkowski Costantino Vetriani Richard Rosario-Passapera Liti Haramaty Eric H. Andrianasolo |
| author_sort | Richard Lutz |
| collection | DOAJ |
| description | Chemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans. |
| first_indexed | 2024-04-14T07:01:23Z |
| format | Article |
| id | doaj.art-65cb9677ab294ab2b263002327a3118c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T07:01:23Z |
| publishDate | 2012-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-65cb9677ab294ab2b263002327a3118c2022-12-22T02:06:45ZengMDPI AGMarine Drugs1660-33972012-10-0110102300231110.3390/md10102300Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificansRichard LutzEileen WhitePaul FalkowskiCostantino VetrianiRichard Rosario-PassaperaLiti HaramatyEric H. AndrianasoloChemical and biological investigation of the cultured marine hydrothermal vent bacterium, Thermovibrio ammonifican led to the isolation of two hydroxyethylamine chromene derivatives, ammonificins C and D. Their structures were elucidated using combination of NMR and mass spectrometry. Absolute stereochemistry was ascertained by comparison of experimental and calculated CD spectra. Biological evaluation and assessment were determined using the patented ApopScreen cell-based screen for apoptosis-induction. Ammonificins C and D induce apoptosis in micromolar concentrations. To our knowledge, this finding is the first report of chemical compounds that induce apoptosis from the cultured deep-sea marine organism, hydrothermal vent bacterium, Thermovibrio ammonificans.http://www.mdpi.com/1660-3397/10/10/2300marine natural productdeep-sea hydrothermal ventdrug discoveryinduction of apoptosisbacteriacomputational methods |
| spellingShingle | Richard Lutz Eileen White Paul Falkowski Costantino Vetriani Richard Rosario-Passapera Liti Haramaty Eric H. Andrianasolo Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans Marine Drugs marine natural product deep-sea hydrothermal vent drug discovery induction of apoptosis bacteria computational methods |
| title | Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans |
| title_full | Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans |
| title_fullStr | Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans |
| title_full_unstemmed | Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans |
| title_short | Ammonificins C and D, Hydroxyethylamine Chromene Derivatives from a Cultured Marine Hydrothermal Vent Bacterium, Thermovibrio ammonificans |
| title_sort | ammonificins c and d hydroxyethylamine chromene derivatives from a cultured marine hydrothermal vent bacterium thermovibrio ammonificans |
| topic | marine natural product deep-sea hydrothermal vent drug discovery induction of apoptosis bacteria computational methods |
| url | http://www.mdpi.com/1660-3397/10/10/2300 |
| work_keys_str_mv | AT richardlutz ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT eileenwhite ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT paulfalkowski ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT costantinovetriani ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT richardrosariopassapera ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT litiharamaty ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans AT erichandrianasolo ammonificinscanddhydroxyethylaminechromenederivativesfromaculturedmarinehydrothermalventbacteriumthermovibrioammonificans |