Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration
We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 IU or 24 IU of oxytocin administration is used. Oxytocin levels were measured in saliva samples collected from 46 female participants right before in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00174/full |
| _version_ | 1818531358274748416 |
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| author | Marinus H. Van IJzendoorn Ritu eBhandari Rixt evan der Veen Karen eGrewen Marian J. Bakermans-Kranenburg |
| author_facet | Marinus H. Van IJzendoorn Ritu eBhandari Rixt evan der Veen Karen eGrewen Marian J. Bakermans-Kranenburg |
| author_sort | Marinus H. Van IJzendoorn |
| collection | DOAJ |
| description | We addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 IU or 24 IU of oxytocin administration is used. Oxytocin levels were measured in saliva samples collected from 46 female participants right before intranasal administration (at 9:30 AM) of 16 IU (n = 18) or 24 IU (n = 10) of oxytocin, or a placebo (n = 18), and each hour after administration, for 7h in total.Oxytocin levels did not differ among conditions before use of the nasal spray. Salivary oxytocin levels in the placebo group showed high stability across the day. After oxytocin administration oxytocin levels markedly increased, they peaked around 1h after administration, and were still significantly elevated 7h after administration. The amount of oxytocin (16 IU or 24 IU) did not make a difference for oxytocin levels. The increase of oxytocin levels for at least 7h shows how effective intranasal administration of oxytocin is. Our findings may raise ethical questions about potentially persisting behavioral effects after participants have left the lab setting. More research into the long-term neurological and behavioral effects of sniffs of oxytocin is urgently needed. |
| first_indexed | 2024-12-11T17:31:26Z |
| format | Article |
| id | doaj.art-65cdc537b5704ba4b7a6ac8ccb1e90be |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T17:31:26Z |
| publishDate | 2012-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-65cdc537b5704ba4b7a6ac8ccb1e90be2022-12-22T00:56:49ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2012-12-01610.3389/fnins.2012.0017438181Elevated salivary levels of oxytocin persist more than seven hours after intranasal administrationMarinus H. Van IJzendoorn0Ritu eBhandari1Rixt evan der Veen2Karen eGrewen3Marian J. Bakermans-Kranenburg4Leiden UniversityLeiden UniversityLeiden UniversityLeiden UniversityLeiden UniversityWe addressed the question how long salivary oxytocin levels remain elevated after intranasal administration, and whether it makes a difference when 16 IU or 24 IU of oxytocin administration is used. Oxytocin levels were measured in saliva samples collected from 46 female participants right before intranasal administration (at 9:30 AM) of 16 IU (n = 18) or 24 IU (n = 10) of oxytocin, or a placebo (n = 18), and each hour after administration, for 7h in total.Oxytocin levels did not differ among conditions before use of the nasal spray. Salivary oxytocin levels in the placebo group showed high stability across the day. After oxytocin administration oxytocin levels markedly increased, they peaked around 1h after administration, and were still significantly elevated 7h after administration. The amount of oxytocin (16 IU or 24 IU) did not make a difference for oxytocin levels. The increase of oxytocin levels for at least 7h shows how effective intranasal administration of oxytocin is. Our findings may raise ethical questions about potentially persisting behavioral effects after participants have left the lab setting. More research into the long-term neurological and behavioral effects of sniffs of oxytocin is urgently needed.http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00174/fullEthicsSalivaintranasal administrationOxytocin; Intranasal administration; Saliva; 16 IU; Behavioral effects; Healthy female volunteers; Daily oxytocin curve; Ethics16 IUBehavioral effects |
| spellingShingle | Marinus H. Van IJzendoorn Ritu eBhandari Rixt evan der Veen Karen eGrewen Marian J. Bakermans-Kranenburg Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration Frontiers in Neuroscience Ethics Saliva intranasal administration Oxytocin; Intranasal administration; Saliva; 16 IU; Behavioral effects; Healthy female volunteers; Daily oxytocin curve; Ethics 16 IU Behavioral effects |
| title | Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| title_full | Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| title_fullStr | Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| title_full_unstemmed | Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| title_short | Elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| title_sort | elevated salivary levels of oxytocin persist more than seven hours after intranasal administration |
| topic | Ethics Saliva intranasal administration Oxytocin; Intranasal administration; Saliva; 16 IU; Behavioral effects; Healthy female volunteers; Daily oxytocin curve; Ethics 16 IU Behavioral effects |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2012.00174/full |
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