Transmission history of SARS-CoV-2 in humans and white-tailed deer
Abstract The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events foll...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16071-z |
| _version_ | 1811294624180862976 |
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| author | Katriina Willgert Xavier Didelot Meera Surendran-Nair Suresh V. Kuchipudi Rachel M. Ruden Michele Yon Ruth H. Nissly Kurt J. Vandegrift Rahul K. Nelli Lingling Li Bhushan M. Jayarao Nicole Levine Randall J. Olsen James J. Davis James M. Musser Peter J. Hudson Vivek Kapur Andrew J. K. Conlan |
| author_facet | Katriina Willgert Xavier Didelot Meera Surendran-Nair Suresh V. Kuchipudi Rachel M. Ruden Michele Yon Ruth H. Nissly Kurt J. Vandegrift Rahul K. Nelli Lingling Li Bhushan M. Jayarao Nicole Levine Randall J. Olsen James J. Davis James M. Musser Peter J. Hudson Vivek Kapur Andrew J. K. Conlan |
| author_sort | Katriina Willgert |
| collection | DOAJ |
| description | Abstract The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events followed by deer-to-deer transmission. Knowledge of the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is essential for effective disease control and prioritisation of interventions. Using genomic data, we reconstruct the transmission history of SARS-CoV-2 in humans and deer, estimate the case finding rate and attempt to infer relative rates of transmission between species. We found no evidence of direct or indirect transmission from deer to human. However, with an estimated case finding rate of only 4.2%, spillback to humans cannot be ruled out. The extensive transmission of SARS-CoV-2 within deer populations and the large number of unsampled cases highlights the need for active surveillance at the human–animal interface. |
| first_indexed | 2024-04-13T05:20:12Z |
| format | Article |
| id | doaj.art-65cdc901ce3f4da592c08f475b18f585 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T05:20:12Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-65cdc901ce3f4da592c08f475b18f5852022-12-22T03:00:47ZengNature PortfolioScientific Reports2045-23222022-07-011211910.1038/s41598-022-16071-zTransmission history of SARS-CoV-2 in humans and white-tailed deerKatriina Willgert0Xavier Didelot1Meera Surendran-Nair2Suresh V. Kuchipudi3Rachel M. Ruden4Michele Yon5Ruth H. Nissly6Kurt J. Vandegrift7Rahul K. Nelli8Lingling Li9Bhushan M. Jayarao10Nicole Levine11Randall J. Olsen12James J. Davis13James M. Musser14Peter J. Hudson15Vivek Kapur16Andrew J. K. Conlan17Disease Dynamics Unit (DDU), Department of Veterinary Medicine, University of CambridgeSchool of Life Sciences and Department of Statistics, University of WarwickAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityWildlife Bureau, Iowa Department of Natural ResourcesAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityThe Center for Infectious Disease Dynamics, Department of Biology and Huck Institutes of the Life Sciences, The Pennsylvania State UniversityDepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State UniversityAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityAnimal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State UniversityHuck Institutes of Life Sciences, The Pennsylvania State UniversityLaboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist HospitalUniversity of Chicago Consortium for Advanced Science and Engineering, University of ChicagoLaboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston Methodist HospitalThe Center for Infectious Disease Dynamics, Department of Biology and Huck Institutes of the Life Sciences, The Pennsylvania State UniversityHuck Institutes of Life Sciences, The Pennsylvania State UniversityDisease Dynamics Unit (DDU), Department of Veterinary Medicine, University of CambridgeAbstract The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events followed by deer-to-deer transmission. Knowledge of the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is essential for effective disease control and prioritisation of interventions. Using genomic data, we reconstruct the transmission history of SARS-CoV-2 in humans and deer, estimate the case finding rate and attempt to infer relative rates of transmission between species. We found no evidence of direct or indirect transmission from deer to human. However, with an estimated case finding rate of only 4.2%, spillback to humans cannot be ruled out. The extensive transmission of SARS-CoV-2 within deer populations and the large number of unsampled cases highlights the need for active surveillance at the human–animal interface.https://doi.org/10.1038/s41598-022-16071-z |
| spellingShingle | Katriina Willgert Xavier Didelot Meera Surendran-Nair Suresh V. Kuchipudi Rachel M. Ruden Michele Yon Ruth H. Nissly Kurt J. Vandegrift Rahul K. Nelli Lingling Li Bhushan M. Jayarao Nicole Levine Randall J. Olsen James J. Davis James M. Musser Peter J. Hudson Vivek Kapur Andrew J. K. Conlan Transmission history of SARS-CoV-2 in humans and white-tailed deer Scientific Reports |
| title | Transmission history of SARS-CoV-2 in humans and white-tailed deer |
| title_full | Transmission history of SARS-CoV-2 in humans and white-tailed deer |
| title_fullStr | Transmission history of SARS-CoV-2 in humans and white-tailed deer |
| title_full_unstemmed | Transmission history of SARS-CoV-2 in humans and white-tailed deer |
| title_short | Transmission history of SARS-CoV-2 in humans and white-tailed deer |
| title_sort | transmission history of sars cov 2 in humans and white tailed deer |
| url | https://doi.org/10.1038/s41598-022-16071-z |
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