Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors.
Calcium signaling represents one of the most important signaling cascades in cells and regulates diverse processes such as exocytosis, muscle contraction and relaxation, gene expression and cell growth. G protein-coupled receptors (GPCRs) are the most important family of receptors that activate calc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3526489?pdf=render |
| _version_ | 1818855786071195648 |
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| author | Roopali Saxena Sourav Ganguly Amitabha Chattopadhyay |
| author_facet | Roopali Saxena Sourav Ganguly Amitabha Chattopadhyay |
| author_sort | Roopali Saxena |
| collection | DOAJ |
| description | Calcium signaling represents one of the most important signaling cascades in cells and regulates diverse processes such as exocytosis, muscle contraction and relaxation, gene expression and cell growth. G protein-coupled receptors (GPCRs) are the most important family of receptors that activate calcium signaling. Since calcium signaling regulates a large number of physiological responses, it is intriguing that how changes in cytosolic calcium levels by a wide range of stimuli lead to signal-specific physiological responses in the cellular interior. In order to address this issue, we have analyzed temporal calcium profiles induced by two GPCRs, the serotonin(1A) and purinergic receptors. In this work, we have described a set of parameters for the analysis of calcium transients that could provide novel insight into mechanisms responsible for maintaining signal specificity by shaping calcium transients. An interesting feature of calcium signaling that has emerged from our analysis is that the profile of individual transients in a calcium response could play an important role in maintaining downstream signal specificity. In summary, our analysis offers a novel approach to identify differences in calcium response patterns induced by various stimuli. |
| first_indexed | 2024-12-19T08:14:08Z |
| format | Article |
| id | doaj.art-65ce003af7e3413e835c5e5e995f6e61 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T08:14:08Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-65ce003af7e3413e835c5e5e995f6e612022-12-21T20:29:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5185710.1371/journal.pone.0051857Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors.Roopali SaxenaSourav GangulyAmitabha ChattopadhyayCalcium signaling represents one of the most important signaling cascades in cells and regulates diverse processes such as exocytosis, muscle contraction and relaxation, gene expression and cell growth. G protein-coupled receptors (GPCRs) are the most important family of receptors that activate calcium signaling. Since calcium signaling regulates a large number of physiological responses, it is intriguing that how changes in cytosolic calcium levels by a wide range of stimuli lead to signal-specific physiological responses in the cellular interior. In order to address this issue, we have analyzed temporal calcium profiles induced by two GPCRs, the serotonin(1A) and purinergic receptors. In this work, we have described a set of parameters for the analysis of calcium transients that could provide novel insight into mechanisms responsible for maintaining signal specificity by shaping calcium transients. An interesting feature of calcium signaling that has emerged from our analysis is that the profile of individual transients in a calcium response could play an important role in maintaining downstream signal specificity. In summary, our analysis offers a novel approach to identify differences in calcium response patterns induced by various stimuli.http://europepmc.org/articles/PMC3526489?pdf=render |
| spellingShingle | Roopali Saxena Sourav Ganguly Amitabha Chattopadhyay Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. PLoS ONE |
| title | Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. |
| title_full | Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. |
| title_fullStr | Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. |
| title_full_unstemmed | Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. |
| title_short | Comparative analysis of calcium spikes upon activation of serotonin(1A) and purinergic receptors. |
| title_sort | comparative analysis of calcium spikes upon activation of serotonin 1a and purinergic receptors |
| url | http://europepmc.org/articles/PMC3526489?pdf=render |
| work_keys_str_mv | AT roopalisaxena comparativeanalysisofcalciumspikesuponactivationofserotonin1aandpurinergicreceptors AT souravganguly comparativeanalysisofcalciumspikesuponactivationofserotonin1aandpurinergicreceptors AT amitabhachattopadhyay comparativeanalysisofcalciumspikesuponactivationofserotonin1aandpurinergicreceptors |