METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10

Abstract Objective N6-methyladenosine (m6A) RNA methylation is involved in governing the mechanism of tumor progression. We aimed to excavate the biological role and mechanism of the m6A methyltransferase METTL3 in cholangiocarcinoma (CCA). Methods METTL3 expression was determined by database and ti...

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Bibliographic Details
Main Authors: Jingli Cai, Zheng Cui, Jingyi Zhou, Bosen Zhang, Ruiqi Lu, Youcheng Ding, Hai Hu
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cancer Cell International
Subjects:
Cholangiocarcinoma
METTL3
AKR1B10
Glycolysis
Online Access:https://doi.org/10.1186/s12935-022-02809-2

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