Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.
Gallbladder cancer (GBC) is the most common biliary tract malignancy with a dismal prognosis. The development of new drugs may help to improve prognosis. This study found that fangchinoline, a bisbenzylisoquinoline alkaloids, inhibited the proliferation and clone formation of GBC cells in a dose-dep...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0266738 |
| _version_ | 1811237486094974976 |
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| author | Jiandong Li Wenda Cen Chenhao Tong Luna Wang Weiguang Zhang Shiqing Deng Jianhua Yu Baochun Lu |
| author_facet | Jiandong Li Wenda Cen Chenhao Tong Luna Wang Weiguang Zhang Shiqing Deng Jianhua Yu Baochun Lu |
| author_sort | Jiandong Li |
| collection | DOAJ |
| description | Gallbladder cancer (GBC) is the most common biliary tract malignancy with a dismal prognosis. The development of new drugs may help to improve prognosis. This study found that fangchinoline, a bisbenzylisoquinoline alkaloids, inhibited the proliferation and clone formation of GBC cells in a dose-dependent manner. Moreover, Hoechst staining, TUNEL assays, and flow cytometry demonstrated that fangchinoline effectively induced apoptosis in GBC cells. Further studies found that an anti-apoptotic pathway, the PI3K/Akt/XIAP axis, was significantly inhibited in GBC cells after treating with fangchinoline. Finally, we confirmed that fangchinoline restrained xenograft tumor growth in vivo. Our findings indicate that fangchinoline can be considered a potential drug for GBC treatment. |
| first_indexed | 2024-04-12T12:24:17Z |
| format | Article |
| id | doaj.art-65cf0579914f482f99a02e18fa406f44 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T12:24:17Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-65cf0579914f482f99a02e18fa406f442022-12-22T03:33:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174e026673810.1371/journal.pone.0266738Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis.Jiandong LiWenda CenChenhao TongLuna WangWeiguang ZhangShiqing DengJianhua YuBaochun LuGallbladder cancer (GBC) is the most common biliary tract malignancy with a dismal prognosis. The development of new drugs may help to improve prognosis. This study found that fangchinoline, a bisbenzylisoquinoline alkaloids, inhibited the proliferation and clone formation of GBC cells in a dose-dependent manner. Moreover, Hoechst staining, TUNEL assays, and flow cytometry demonstrated that fangchinoline effectively induced apoptosis in GBC cells. Further studies found that an anti-apoptotic pathway, the PI3K/Akt/XIAP axis, was significantly inhibited in GBC cells after treating with fangchinoline. Finally, we confirmed that fangchinoline restrained xenograft tumor growth in vivo. Our findings indicate that fangchinoline can be considered a potential drug for GBC treatment.https://doi.org/10.1371/journal.pone.0266738 |
| spellingShingle | Jiandong Li Wenda Cen Chenhao Tong Luna Wang Weiguang Zhang Shiqing Deng Jianhua Yu Baochun Lu Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. PLoS ONE |
| title | Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. |
| title_full | Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. |
| title_fullStr | Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. |
| title_full_unstemmed | Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. |
| title_short | Fangchinoline induces gallbladder cancer cell apoptosis by suppressing PI3K/Akt/XIAP axis. |
| title_sort | fangchinoline induces gallbladder cancer cell apoptosis by suppressing pi3k akt xiap axis |
| url | https://doi.org/10.1371/journal.pone.0266738 |
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