Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy

Inhibiting the inflammasome with MCC950 counteracts muscle pyroptosis and improves Duchenne muscular dystrophy

BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression. Previously, we reported that the NLRP3 inflammasome complex plays a crucial role in this disorder. More...

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Bibliographic Details
Main Authors: Nicolas Dubuisson, María A. Davis-López de Carrizosa, Romain Versele, Camille M. Selvais, Laurence Noel, P. Y. D. Van den Bergh, Sonia M. Brichard, Michel Abou-Samra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
Duchenne muscular dystrophy (DMD)
MCC950
NLRP3 inflammasome
pyroptosis
muscle inflammation
gasdermin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049076/full

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