Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel <i>USP8</i> Gene Variant

Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel <i>USP8</i> Gene Variant

Cushing’s Disease (CD) is a rare condition characterized by an overproduction of ACTH by an ACTH-secreting pituitary tumor, resulting in an excess of cortisol release by the adrenal glands. Somatic mutations in the deubiquitinases <i>USP8</i> and <i>USP48</i>, and in <i>...

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Bibliographic Details
Main Authors: Donatella Treppiedi, Anna Maria Barbieri, Genesio Di Muro, Giusy Marra, Federica Mangili, Rosa Catalano, Emanuela Esposito, Emanuele Ferrante, Andreea Liliana Serban, Marco Locatelli, Andrea Gerardo Lania, Anna Spada, Maura Arosio, Erika Peverelli, Giovanna Mantovani
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
Cushing’s disease
ACTH-secreting pituitary tumor
USP8
USP48
mutation
Online Access:https://www.mdpi.com/2072-6694/13/16/4022

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