CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis
Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface g...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2018-12-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100610&lng=en&tlng=en |
| _version_ | 1811265313581301760 |
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| author | A. Nonino J.M. Nascimento C.C. Mascarenhas J.F. Mazzeu R.W. Pereira R.H. Jacomo |
| author_facet | A. Nonino J.M. Nascimento C.C. Mascarenhas J.F. Mazzeu R.W. Pereira R.H. Jacomo |
| author_sort | A. Nonino |
| collection | DOAJ |
| description | Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocytosis inhibitor of the expressing cell, that is increased in normal hematopoietic stem and progenitor cells mobilized into the blood and several human cancer-initiating cells, such as in acute myeloid leukemia. We compared CD47 expression in hematopoietic stem and progenitor cells of patients with MF and controls and found it to be decreased in progenitors of MF. Exposure of control HPCs to the cytokines transforming growth factor β and stromal-derived factor 1, which are important regulators of hematopoietic stem cell cycling and are overexpressed in patients with MF, did not modulate CD47 expression. |
| first_indexed | 2024-04-12T20:20:38Z |
| format | Article |
| id | doaj.art-65d50cb34fc6471ba657dc138d704658 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-12T20:20:38Z |
| publishDate | 2018-12-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-65d50cb34fc6471ba657dc138d7046582022-12-22T03:18:00ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2018-12-0152110.1590/1414-431x20187784S0100-879X2019000100610CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosisA. NoninoJ.M. NascimentoC.C. MascarenhasJ.F. MazzeuR.W. PereiraR.H. JacomoMyelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocytosis inhibitor of the expressing cell, that is increased in normal hematopoietic stem and progenitor cells mobilized into the blood and several human cancer-initiating cells, such as in acute myeloid leukemia. We compared CD47 expression in hematopoietic stem and progenitor cells of patients with MF and controls and found it to be decreased in progenitors of MF. Exposure of control HPCs to the cytokines transforming growth factor β and stromal-derived factor 1, which are important regulators of hematopoietic stem cell cycling and are overexpressed in patients with MF, did not modulate CD47 expression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100610&lng=en&tlng=enMyeloproliferative disordersPrimary myelofibrosisHematopoietic stem cellsNeoplastic stem cellsAntigensCD47 |
| spellingShingle | A. Nonino J.M. Nascimento C.C. Mascarenhas J.F. Mazzeu R.W. Pereira R.H. Jacomo CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis Brazilian Journal of Medical and Biological Research Myeloproliferative disorders Primary myelofibrosis Hematopoietic stem cells Neoplastic stem cells Antigens CD47 |
| title | CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| title_full | CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| title_fullStr | CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| title_full_unstemmed | CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| title_short | CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| title_sort | cd47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis |
| topic | Myeloproliferative disorders Primary myelofibrosis Hematopoietic stem cells Neoplastic stem cells Antigens CD47 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100610&lng=en&tlng=en |
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