Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study
BackgroundEmerging evidence has been reported of attentional dysfunction in pituitary adenoma patients. However, the effect of pituitary adenomas on lateralized attention network efficiency remained to be clear. Thus, the present study aimed to investigate the impairment of lateralized attention net...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1198409/full |
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| author | Shuochen Wang Shuochen Wang Zhenghao Fu Zhenghao Fu Yuanyi Sun Yuanyi Sun Meng Zhang Aobo Chen Chenglong Cao Jian Song Jian Song |
| author_facet | Shuochen Wang Shuochen Wang Zhenghao Fu Zhenghao Fu Yuanyi Sun Yuanyi Sun Meng Zhang Aobo Chen Chenglong Cao Jian Song Jian Song |
| author_sort | Shuochen Wang |
| collection | DOAJ |
| description | BackgroundEmerging evidence has been reported of attentional dysfunction in pituitary adenoma patients. However, the effect of pituitary adenomas on lateralized attention network efficiency remained to be clear. Thus, the present study aimed to investigate the impairment of lateralized attention networks in patients with pituitary adenoma.MethodsEighteen pituitary adenoma patients (PA group) and 20 healthy controls (HCs) were included in this study. Both behavioral results and event-related potentials (ERPs) were acquired while subjects performed the Lateralized Attention Network Test (LANT).ResultsBehavioral performances indicated the PA group had a slower reaction time and a similar error rate relative to the HCs group. Meanwhile, significantly increased executive control network efficiency suggested the dysfunction of inhibition control in PA patients. Regarding ERP results, there were no group differences in the alerting and orienting networks. The target-related P3 was significantly reduced in the PA group, suggesting an impairment of executive control function and attentional resources allocation. Moreover, the mean amplitude of P3 was significantly lateralized to the right hemisphere, and interacted with the visual field, exhibiting that the right hemisphere dominated the bilateral visual field, whereas the left hemisphere dominated the left visual field. In the specific high-conflict condition, the pattern of hemispheric asymmetry in the PA group was altered due to a mixed effect resulting from the compensatory recruitment of attentional resources in the left central parietal area and the destructive effects of hyperprolactinemia.ConclusionThese findings suggested that, in the lateralized condition, the decreased P3 in the right central parietal area and the diminished hemispheric asymmetry under high conflict load, may serve as the potential biomarkers of attentional dysfunction in patients with pituitary adenoma. |
| first_indexed | 2024-04-09T13:17:52Z |
| format | Article |
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| language | English |
| last_indexed | 2024-04-09T13:17:52Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-65d52f35ff7a4b0eaf9090801c1931532023-05-11T14:35:44ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-05-011710.3389/fnins.2023.11984091198409Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential studyShuochen Wang0Shuochen Wang1Zhenghao Fu2Zhenghao Fu3Yuanyi Sun4Yuanyi Sun5Meng Zhang6Aobo Chen7Chenglong Cao8Jian Song9Jian Song10The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurosurgery, The General Hospital of Central Theater Command, Wuhan, Hubei, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurosurgery, The General Hospital of Central Theater Command, Wuhan, Hubei, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurosurgery, The General Hospital of Central Theater Command, Wuhan, Hubei, ChinaDepartment of Neurosurgery, The General Hospital of Central Theater Command, Wuhan, Hubei, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, ChinaDepartment of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, ChinaThe First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Neurosurgery, The General Hospital of Central Theater Command, Wuhan, Hubei, ChinaBackgroundEmerging evidence has been reported of attentional dysfunction in pituitary adenoma patients. However, the effect of pituitary adenomas on lateralized attention network efficiency remained to be clear. Thus, the present study aimed to investigate the impairment of lateralized attention networks in patients with pituitary adenoma.MethodsEighteen pituitary adenoma patients (PA group) and 20 healthy controls (HCs) were included in this study. Both behavioral results and event-related potentials (ERPs) were acquired while subjects performed the Lateralized Attention Network Test (LANT).ResultsBehavioral performances indicated the PA group had a slower reaction time and a similar error rate relative to the HCs group. Meanwhile, significantly increased executive control network efficiency suggested the dysfunction of inhibition control in PA patients. Regarding ERP results, there were no group differences in the alerting and orienting networks. The target-related P3 was significantly reduced in the PA group, suggesting an impairment of executive control function and attentional resources allocation. Moreover, the mean amplitude of P3 was significantly lateralized to the right hemisphere, and interacted with the visual field, exhibiting that the right hemisphere dominated the bilateral visual field, whereas the left hemisphere dominated the left visual field. In the specific high-conflict condition, the pattern of hemispheric asymmetry in the PA group was altered due to a mixed effect resulting from the compensatory recruitment of attentional resources in the left central parietal area and the destructive effects of hyperprolactinemia.ConclusionThese findings suggested that, in the lateralized condition, the decreased P3 in the right central parietal area and the diminished hemispheric asymmetry under high conflict load, may serve as the potential biomarkers of attentional dysfunction in patients with pituitary adenoma.https://www.frontiersin.org/articles/10.3389/fnins.2023.1198409/fullevent-related potentialslateralized attention network testhemispheric asymmetryalertingorientingexecutive control |
| spellingShingle | Shuochen Wang Shuochen Wang Zhenghao Fu Zhenghao Fu Yuanyi Sun Yuanyi Sun Meng Zhang Aobo Chen Chenglong Cao Jian Song Jian Song Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study Frontiers in Neuroscience event-related potentials lateralized attention network test hemispheric asymmetry alerting orienting executive control |
| title | Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study |
| title_full | Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study |
| title_fullStr | Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study |
| title_full_unstemmed | Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study |
| title_short | Altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma: an event-related potential study |
| title_sort | altered hemispheric asymmetry of attentional networks in patients with pituitary adenoma an event related potential study |
| topic | event-related potentials lateralized attention network test hemispheric asymmetry alerting orienting executive control |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1198409/full |
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