Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system
Abstract In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to charact...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21253-w |
| _version_ | 1798044365972570112 |
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| author | Erika Horta Conor Burke-Smith Bryant W. Megna Kendall J. Nichols Byron P. Vaughn Rwoof Reshi Eugenia Shmidt |
| author_facet | Erika Horta Conor Burke-Smith Bryant W. Megna Kendall J. Nichols Byron P. Vaughn Rwoof Reshi Eugenia Shmidt |
| author_sort | Erika Horta |
| collection | DOAJ |
| description | Abstract In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic distribution, and risk factors for CVA in patients with UC. We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered. Prevalence of CVAs in patients with UC was compared to that of the general population of Minnesota (MN) and the United States (U.S.). A total of 2,183 UC patients were identified (1088 females [f-UC], 1095 males [m-UC]). The prevalence of CVA in UC patients (4.7%, 95% CI 3.9–5.6) was higher than in the U.S. (2.5–2.7%, p < 0.0001) and in Minnesota (1.8% CI 1.5–2.2, p < 0.0001) . The prevalence increased in both sexes with a peak prevalence of 24.7% (95% CI 17.1–34.4) in women with UC over the age of 80. Older age, cancer and atrial fibrillation were risk factors for CVA in univariate analysis for both sexes. In multifactorial analysis, both age and atrial fibrillation were risk factors for CVA in the m-UC cohort, but only age was associated with CVA in f-UC. The most common type of CVA was ischemic stroke (77.7%). The most common locations for CVAs in UC patients were frontal and occipital lobes (19% and 18%, respectively). UC patients have an increased risk for CVA, with women over 80 demonstrating the highest risk. Providers should be aware of these risks in making treatment decisions for UC. |
| first_indexed | 2024-04-11T23:02:41Z |
| format | Article |
| id | doaj.art-65d656024ece4e0c9574e6d0e46bb47f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T23:02:41Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-65d656024ece4e0c9574e6d0e46bb47f2022-12-22T03:58:05ZengNature PortfolioScientific Reports2045-23222022-11-011211710.1038/s41598-022-21253-wPrevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health systemErika Horta0Conor Burke-Smith1Bryant W. Megna2Kendall J. Nichols3Byron P. Vaughn4Rwoof Reshi5Eugenia Shmidt6Department of Neurology, University of Arkansas Medical SciencesUniversity of Iowa Carver College of MedicineInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of MinnesotaDepartment of Neurology, University of MinnesotaInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of MinnesotaThe University of Oklahoma Health Sciences CenterInflammatory Bowel Disease Program, Department of Gastroenterology and Hepatology, University of MinnesotaAbstract In general, IBD increases arteriovenous thromboembolic events, though the association between UC and cerebrovascular complications remains inconclusive. Some studies suggest young women with UC have an increased risk of cerebrovascular accidents (CVA). The focus of this study was to characterize the rates, anatomic distribution, and risk factors for CVA in patients with UC. We developed a retrospective cohort of patients with UC at a single health care system from June 2010 to June 2015. Neuroimaging was used to document presence, location and type of stroke and traditional risk factors were considered. Prevalence of CVAs in patients with UC was compared to that of the general population of Minnesota (MN) and the United States (U.S.). A total of 2,183 UC patients were identified (1088 females [f-UC], 1095 males [m-UC]). The prevalence of CVA in UC patients (4.7%, 95% CI 3.9–5.6) was higher than in the U.S. (2.5–2.7%, p < 0.0001) and in Minnesota (1.8% CI 1.5–2.2, p < 0.0001) . The prevalence increased in both sexes with a peak prevalence of 24.7% (95% CI 17.1–34.4) in women with UC over the age of 80. Older age, cancer and atrial fibrillation were risk factors for CVA in univariate analysis for both sexes. In multifactorial analysis, both age and atrial fibrillation were risk factors for CVA in the m-UC cohort, but only age was associated with CVA in f-UC. The most common type of CVA was ischemic stroke (77.7%). The most common locations for CVAs in UC patients were frontal and occipital lobes (19% and 18%, respectively). UC patients have an increased risk for CVA, with women over 80 demonstrating the highest risk. Providers should be aware of these risks in making treatment decisions for UC.https://doi.org/10.1038/s41598-022-21253-w |
| spellingShingle | Erika Horta Conor Burke-Smith Bryant W. Megna Kendall J. Nichols Byron P. Vaughn Rwoof Reshi Eugenia Shmidt Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system Scientific Reports |
| title | Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| title_full | Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| title_fullStr | Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| title_full_unstemmed | Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| title_short | Prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| title_sort | prevalence of cerebrovascular accidents in patients with ulcerative colitis in a single academic health system |
| url | https://doi.org/10.1038/s41598-022-21253-w |
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