Effect of Priming Dose Rocuronium Use on Intubation Quality and Duration
Introduction: This study aimed to investigate the effects of priming dose application with rocuronium, considering ideal body weight (IBW), on intubation quality and duration during the use of rocuronium and vecuronium as neuromuscular blockers. Methods: Our study was conducted at University of Heal...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2023-11-01
|
| Series: | İstanbul Medical Journal |
| Subjects: | |
| Online Access: |
http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/effect-of-priming-dose-rocuronium-use-on-ntubation/63658
|
| Summary: | Introduction: This study aimed to investigate the effects of priming dose application with rocuronium, considering ideal body weight (IBW), on intubation quality and duration during the use of rocuronium and vecuronium as neuromuscular blockers. Methods: Our study was conducted at University of Health Sciences Turkey, Haseki Training and Research Hospital on 60 patients who were in the American Society of Anesthesiology I-II group, aged between 20-70, Mallampati I-II-III, body mass index between 20-35, and planned for medium-term elective surgical intervention. The patients were randomly divided into four groups. Group I was administered a priming dose of rocuronium 0.06 mg/kg and rocuronium 0.54 mg/kg following anesthesia induction, and group II was administered a priming dose of saline and 0.1 mg/kg vecuronium following anesthesia induction, and group III was administered a priming dose of rocuronium 0.06 mg/kg and vecuronium 0.1 mg/kg following anesthesia induction, and group IV was administered a saline priming dose and rocuronium 0.6 mg/kg following anesthesia induction. Priming and intubation doses of neuromuscular blockers were calculated according to the IBW of the patients. In addition to routine monitoring, the TOF-Guard device was used for neuromonitoring, and the T95 onset time [the time from the end of the muscle relaxant injection until maximum neuromuscular block (95%) was achieved] was recorded. The same person intubated the patients when the TOF value decreased to 5% or below. The quality of endotracheal intubation was assessed using the Clarke and Mirakhur scale. Statistical analyses were performed using SPSS 18.0 software. Results: The effect onset time of group 1, in which rocuronium was used as a neuromuscular blocker and priming application, was significantly shorter than that of group 4, in which bolus dose rocuronium was used. Although the effect onset time of vecuronium in group 3, primed with rocuronium, was shorter than that in group 2, where the bolus dose of vecuronium was used, the difference was not observed to be significant. Conclusion: As a result, it was concluded that priming dose application with rocuronium accelerates the neuromuscular block created by rocuronium, has no significant effect on the rate of neuromuscular block created by vecuronium, and provides excellent intubation conditions. It provides fast, high quality, and safe intubation in rapid induction required cases. |
|---|---|
| ISSN: | 2619-9793 2148-094X |