Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome
Introduction: Sticky platelet syndrome (SPS) is referred to as a platelet hyperaggregability triggered by low concentrations of platelet agonists adenosine diphosphate (ADP) and/or epinephrine (EPI). Platelet aggregation with other inducers (collagen, arachidonic acid, ristocetin, and thrombin) rema...
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2019-12-01
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| Series: | Acta Medica Martiniana |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acm-2019-0012 |
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| author | Vadelova L Ivankova J Sokol J Skerenova M Zolkova J Vazanova A Skornova I Stasko J |
| author_facet | Vadelova L Ivankova J Sokol J Skerenova M Zolkova J Vazanova A Skornova I Stasko J |
| author_sort | Vadelova L |
| collection | DOAJ |
| description | Introduction: Sticky platelet syndrome (SPS) is referred to as a platelet hyperaggregability triggered by low concentrations of platelet agonists adenosine diphosphate (ADP) and/or epinephrine (EPI). Platelet aggregation with other inducers (collagen, arachidonic acid, ristocetin, and thrombin) remains within a normal range. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in post-transcriptional regulation of protein expression. More recently, several studies show that the platelets are an abundant source of miRNAs and that the miRNA expression profiles within platelets correlate with the platelet reactivity. |
| first_indexed | 2024-03-12T23:16:24Z |
| format | Article |
| id | doaj.art-65da53ff183a4aa89de0f2f1d78651c3 |
| institution | Directory Open Access Journal |
| issn | 1338-4139 |
| language | English |
| last_indexed | 2024-03-12T23:16:24Z |
| publishDate | 2019-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Medica Martiniana |
| spelling | doaj.art-65da53ff183a4aa89de0f2f1d78651c32023-07-17T05:26:05ZengSciendoActa Medica Martiniana1338-41392019-12-01193889410.2478/acm-2019-0012Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet SyndromeVadelova L0Ivankova J1Sokol J2Skerenova M3Zolkova J4Vazanova A5Skornova I6Stasko J7Department of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDivison of Molecular Medicine, Biomedical Center Martin Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaDepartment of Hematology and Transfusiology, National Centre of Hemostasis and Thrombosis, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin University Hospital, Martin, SlovakiaIntroduction: Sticky platelet syndrome (SPS) is referred to as a platelet hyperaggregability triggered by low concentrations of platelet agonists adenosine diphosphate (ADP) and/or epinephrine (EPI). Platelet aggregation with other inducers (collagen, arachidonic acid, ristocetin, and thrombin) remains within a normal range. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in post-transcriptional regulation of protein expression. More recently, several studies show that the platelets are an abundant source of miRNAs and that the miRNA expression profiles within platelets correlate with the platelet reactivity.https://doi.org/10.2478/acm-2019-0012plateletmagnetic separationsticky platelet syndromeplatelet mirna |
| spellingShingle | Vadelova L Ivankova J Sokol J Skerenova M Zolkova J Vazanova A Skornova I Stasko J Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome Acta Medica Martiniana platelet magnetic separation sticky platelet syndrome platelet mirna |
| title | Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome |
| title_full | Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome |
| title_fullStr | Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome |
| title_full_unstemmed | Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome |
| title_short | Our First Experience with Magnetic Separation of Platelets for Analyses of Platelet MicroRNA in Patients with Sticky Platelet Syndrome |
| title_sort | our first experience with magnetic separation of platelets for analyses of platelet microrna in patients with sticky platelet syndrome |
| topic | platelet magnetic separation sticky platelet syndrome platelet mirna |
| url | https://doi.org/10.2478/acm-2019-0012 |
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