Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors

Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors

Background: Protein disulphide isomerase (PDI) and NADPH oxidase 1 (Nox-1) regulate platelet function and reactive oxygen species (ROS) generation, suggesting potentially interdependent roles. Increased platelet reactivity and ROS production have been correlated with cardiometabolic disease risk fac...

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Bibliographic Details
Main Authors: Renato Simões Gaspar, Tanya Sage, Gemma Little, Neline Kriek, Giordano Pula, Jonathan M. Gibbins
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
platelets
protein disulphide isomerase
NADPH oxidase
metabolic syndrome
redox biology
Online Access:https://www.mdpi.com/2076-3921/10/3/497

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