Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults?
Data on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45–64 years from the 45 and Up Study who were free of cancer, depression, and anxiety at baseline (2006–2009). The incidence of cancer, mental disorders, and multimo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1700 |
| _version_ | 1797564078170832896 |
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| author | Xianwen Shang Allison M. Hodge Wei Peng Mingguang He Lei Zhang |
| author_facet | Xianwen Shang Allison M. Hodge Wei Peng Mingguang He Lei Zhang |
| author_sort | Xianwen Shang |
| collection | DOAJ |
| description | Data on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45–64 years from the 45 and Up Study who were free of cancer, depression, and anxiety at baseline (2006–2009). The incidence of cancer, mental disorders, and multimorbidity (concurrent cancer and mental disorders) was identified using claim databases during follow-up until 31 December 2016. During a nine-year follow-up, the cumulative incidence of cancer, mental disorders, and multimorbidity was 8.8%, 17.4%, and 2.2%, respectively. Participants with cancer were 3.41 times more likely to develop mental disorders, while individuals with mental disorders were 3.06 times more likely to develop cancer than people without these conditions. The shared risk factors for cancer and mental disorders were older age, female gender, smoking, psychological distress, low fruit intake, poor/fair self-rated health, hypertension, arthritis, asthma, and diabetes. Low education, low income, overweight/obesity, and family history of depression were risk factors for mental disorders and multimorbidity but not cancer. In conclusion, smoking, low fruit intake, and obesity are key modifiable factors for the prevention of cancer and mental disorders. Individuals with poor/fair self-rated health, high psychological distress, asthma, hypertension, arthritis, or diabetes should be targeted for the prevention and screening of cancer and mental disorders. |
| first_indexed | 2024-03-10T18:52:20Z |
| format | Article |
| id | doaj.art-65dd440aeb284d74a367f41ceb9c3338 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T18:52:20Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-65dd440aeb284d74a367f41ceb9c33382023-11-20T05:01:51ZengMDPI AGCancers2072-66942020-06-01126170010.3390/cancers12061700Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults?Xianwen Shang0Allison M. Hodge1Wei Peng2Mingguang He3Lei Zhang4Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC 3004, AustraliaResearch Centre for Data Analytics and Cognition, La Trobe University, Melbourne, VIC 3083, AustraliaCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, AustraliaData on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45–64 years from the 45 and Up Study who were free of cancer, depression, and anxiety at baseline (2006–2009). The incidence of cancer, mental disorders, and multimorbidity (concurrent cancer and mental disorders) was identified using claim databases during follow-up until 31 December 2016. During a nine-year follow-up, the cumulative incidence of cancer, mental disorders, and multimorbidity was 8.8%, 17.4%, and 2.2%, respectively. Participants with cancer were 3.41 times more likely to develop mental disorders, while individuals with mental disorders were 3.06 times more likely to develop cancer than people without these conditions. The shared risk factors for cancer and mental disorders were older age, female gender, smoking, psychological distress, low fruit intake, poor/fair self-rated health, hypertension, arthritis, asthma, and diabetes. Low education, low income, overweight/obesity, and family history of depression were risk factors for mental disorders and multimorbidity but not cancer. In conclusion, smoking, low fruit intake, and obesity are key modifiable factors for the prevention of cancer and mental disorders. Individuals with poor/fair self-rated health, high psychological distress, asthma, hypertension, arthritis, or diabetes should be targeted for the prevention and screening of cancer and mental disorders.https://www.mdpi.com/2072-6694/12/6/1700multimorbiditycancermental disordersshared risk factorsleading risk factorsmachine learning |
| spellingShingle | Xianwen Shang Allison M. Hodge Wei Peng Mingguang He Lei Zhang Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? Cancers multimorbidity cancer mental disorders shared risk factors leading risk factors machine learning |
| title | Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? |
| title_full | Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? |
| title_fullStr | Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? |
| title_full_unstemmed | Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? |
| title_short | Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults? |
| title_sort | are leading risk factors for cancer and mental disorders multimorbidity shared by these two individual conditions in community dwelling middle aged adults |
| topic | multimorbidity cancer mental disorders shared risk factors leading risk factors machine learning |
| url | https://www.mdpi.com/2072-6694/12/6/1700 |
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