Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

Human-specific evolutionary markers linked to foetal neurodevelopment modulate brain surface area in schizophrenia

Abstract Schizophrenia may represent a trade-off in the evolution of human-specific ontogenetic mechanisms that guide neurodevelopment. Human Accelerated Regions (HARs) are evolutionary markers functioning as neurodevelopmental transcription enhancers that have been associated with brain configurati...

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Main Authors: Maria Guardiola-Ripoll, Carmen Almodóvar-Payá, Angelo Arias-Magnasco, Mariona Latorre-Guardia, Sergi Papiol, Erick J. Canales-Rodríguez, María Ángeles García-León, Paola Fuentes-Claramonte, Josep Salavert, Josep Tristany, Llanos Torres, Elena Rodríguez-Cano, Raymond Salvador, Edith Pomarol-Clotet, Mar Fatjó-Vilas
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-05356-2

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