Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer
2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose (FDG) uptake of the reticuloendothelial system, including the bone marrow (BM) and spleen, on positron emission tomography/computed tomography (PET/CT) has been shown to be a significant prognostic factor in diverse malignancies. However, the re...
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MDPI AG
2023-03-01
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| Online Access: | https://www.mdpi.com/2075-1729/13/3/771 |
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| author | Hyein Ahn Geum Jong Song Moon-Soo Lee Ji-Hye Lee Si-Hyong Jang Mee-Hye Oh Jong Hyuk Yun Sang Mi Lee Jeong Won Lee |
| author_facet | Hyein Ahn Geum Jong Song Moon-Soo Lee Ji-Hye Lee Si-Hyong Jang Mee-Hye Oh Jong Hyuk Yun Sang Mi Lee Jeong Won Lee |
| author_sort | Hyein Ahn |
| collection | DOAJ |
| description | 2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose (FDG) uptake of the reticuloendothelial system, including the bone marrow (BM) and spleen, on positron emission tomography/computed tomography (PET/CT) has been shown to be a significant prognostic factor in diverse malignancies. However, the relationship between FDG uptake of the BM and spleen and histopathological findings, including the tumor immune microenvironment, has not been fully evaluated. This study aimed to investigate the relationship of FDG uptake in the BM and spleen with histopathological findings and recurrence-free survival (RFS) in patients with gastric cancer. Seventy patients with gastric cancer who underwent pre-operative FDG PET/CT and subsequent curative surgery were retrospectively enrolled. On image analysis, the BM-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) were measured from PET/CT images, and on immunohistochemical analysis, the densities of immune cell infiltration in the tumor tissue were graded. The BLR and SLR showed significant positive correlations with the grades of CD163 cell and CD8 cell infiltration in the tumor tissue, respectively (<i>p</i> < 0.05). In multivariate survival analysis, both BLR and SLR were significant predictors of RFS (<i>p</i> < 0.05). FDG uptake in the BM and spleen might be potential imaging biomarkers for evaluating tumor immune microenvironment conditions and predicting RFS in patients with gastric cancer. |
| first_indexed | 2024-03-11T06:17:15Z |
| format | Article |
| id | doaj.art-65ddb2c820454b318c2059392d50065b |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T06:17:15Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-65ddb2c820454b318c2059392d50065b2023-11-17T12:12:08ZengMDPI AGLife2075-17292023-03-0113377110.3390/life13030771Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric CancerHyein Ahn0Geum Jong Song1Moon-Soo Lee2Ji-Hye Lee3Si-Hyong Jang4Mee-Hye Oh5Jong Hyuk Yun6Sang Mi Lee7Jeong Won Lee8Department of Pathology, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Surgery, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Surgery, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Pathology, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Pathology, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Pathology, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Surgery, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of KoreaDepartment of Nuclear Medicine, College of Medicine, Catholic Kwandong University, International St. Mary’s Hospital, 25 Simgok-ro 100-gil, Seo-gu, Incheon 22711, Republic of Korea2-deoxy-2-[<sup>18</sup>F]fluoro-D-glucose (FDG) uptake of the reticuloendothelial system, including the bone marrow (BM) and spleen, on positron emission tomography/computed tomography (PET/CT) has been shown to be a significant prognostic factor in diverse malignancies. However, the relationship between FDG uptake of the BM and spleen and histopathological findings, including the tumor immune microenvironment, has not been fully evaluated. This study aimed to investigate the relationship of FDG uptake in the BM and spleen with histopathological findings and recurrence-free survival (RFS) in patients with gastric cancer. Seventy patients with gastric cancer who underwent pre-operative FDG PET/CT and subsequent curative surgery were retrospectively enrolled. On image analysis, the BM-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) were measured from PET/CT images, and on immunohistochemical analysis, the densities of immune cell infiltration in the tumor tissue were graded. The BLR and SLR showed significant positive correlations with the grades of CD163 cell and CD8 cell infiltration in the tumor tissue, respectively (<i>p</i> < 0.05). In multivariate survival analysis, both BLR and SLR were significant predictors of RFS (<i>p</i> < 0.05). FDG uptake in the BM and spleen might be potential imaging biomarkers for evaluating tumor immune microenvironment conditions and predicting RFS in patients with gastric cancer.https://www.mdpi.com/2075-1729/13/3/771bone marrowF-18 fluorodeoxyglucosepositron emission tomographyprognosisspleenstomach neoplasm |
| spellingShingle | Hyein Ahn Geum Jong Song Moon-Soo Lee Ji-Hye Lee Si-Hyong Jang Mee-Hye Oh Jong Hyuk Yun Sang Mi Lee Jeong Won Lee Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer Life bone marrow F-18 fluorodeoxyglucose positron emission tomography prognosis spleen stomach neoplasm |
| title | Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer |
| title_full | Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer |
| title_fullStr | Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer |
| title_full_unstemmed | Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer |
| title_short | Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer |
| title_sort | relationship of fdg uptake of the reticuloendothelial system with tumor immune microenvironment and prognosis in patients with gastric cancer |
| topic | bone marrow F-18 fluorodeoxyglucose positron emission tomography prognosis spleen stomach neoplasm |
| url | https://www.mdpi.com/2075-1729/13/3/771 |
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