A Review of Applications of Nanoceria in Cancer
Cancer is one of the most difficult diseases to treat in modern medicine. Annually, many articles are published that propose various ways for preventing carcinogenesis. Furthermore, research into cancer treatments is carried out with minimal side effects. The most common non-invasive cancer treatmen...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2022-10-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18223-en.html |
| _version_ | 1797893151038373888 |
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| author | Zahra Shaghaghi Maryam Alvandi Soghra Farzipour Fereshteh Talebpour Amiri Mohammadreza Dehbanpour |
| author_facet | Zahra Shaghaghi Maryam Alvandi Soghra Farzipour Fereshteh Talebpour Amiri Mohammadreza Dehbanpour |
| author_sort | Zahra Shaghaghi |
| collection | DOAJ |
| description | Cancer is one of the most difficult diseases to treat in modern medicine. Annually, many articles are published that propose various ways for preventing carcinogenesis. Furthermore, research into cancer treatments is carried out with minimal side effects. The most common non-invasive cancer treatments include chemotherapy, targeted therapy, radiotherapy, and immunotherapy. Low effectiveness of chemo-radiation therapy and normal tissue toxicity caused by these treatments are two of the most difficult challenges. Some medicines have been recommended as adjuvants to increase tumor responses while also reducing normal tissue damage. Cerium oxide as a nanoparticle (nanoceria, CNPs) has recieved a lot of interest as a way to control tumor and normal tissue responses to various cancer treatment regimens. In vitro and in vivo studies demonstrate that it can reduce chemo-radiation toxicity in normal tissues as an antioxidant and anti-inflammatory agent. Furthermore, it has the ability to make cancer cells more sensitive to both chemotherapy and radiotherapy. In this paper, we reviewed the potential role of nanoceria for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities. |
| first_indexed | 2024-04-10T06:49:27Z |
| format | Article |
| id | doaj.art-65e0e6a004cc4f3581eb7e5e9236121e |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T06:49:27Z |
| publishDate | 2022-10-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-65e0e6a004cc4f3581eb7e5e9236121e2023-02-28T09:08:45ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792022-10-0132213186200A Review of Applications of Nanoceria in CancerZahra Shaghaghi0Maryam Alvandi1Soghra Farzipour2Fereshteh Talebpour Amiri3Mohammadreza Dehbanpour4 Assistant Professor, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Associate Professor, Department of Nuclear Medicine and Molecular Imaging, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Assistant Professor, Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran Associate Professor, Department of Anatomy, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran BSc in Radiology, Faculty of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran Cancer is one of the most difficult diseases to treat in modern medicine. Annually, many articles are published that propose various ways for preventing carcinogenesis. Furthermore, research into cancer treatments is carried out with minimal side effects. The most common non-invasive cancer treatments include chemotherapy, targeted therapy, radiotherapy, and immunotherapy. Low effectiveness of chemo-radiation therapy and normal tissue toxicity caused by these treatments are two of the most difficult challenges. Some medicines have been recommended as adjuvants to increase tumor responses while also reducing normal tissue damage. Cerium oxide as a nanoparticle (nanoceria, CNPs) has recieved a lot of interest as a way to control tumor and normal tissue responses to various cancer treatment regimens. In vitro and in vivo studies demonstrate that it can reduce chemo-radiation toxicity in normal tissues as an antioxidant and anti-inflammatory agent. Furthermore, it has the ability to make cancer cells more sensitive to both chemotherapy and radiotherapy. In this paper, we reviewed the potential role of nanoceria for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.http://jmums.mazums.ac.ir/article-1-18223-en.htmlcerium oxide nanoparticlesprotective effectsensitizing effectchemotherapyradiotherapy |
| spellingShingle | Zahra Shaghaghi Maryam Alvandi Soghra Farzipour Fereshteh Talebpour Amiri Mohammadreza Dehbanpour A Review of Applications of Nanoceria in Cancer Journal of Mazandaran University of Medical Sciences cerium oxide nanoparticles protective effect sensitizing effect chemotherapy radiotherapy |
| title | A Review of Applications of Nanoceria in Cancer |
| title_full | A Review of Applications of Nanoceria in Cancer |
| title_fullStr | A Review of Applications of Nanoceria in Cancer |
| title_full_unstemmed | A Review of Applications of Nanoceria in Cancer |
| title_short | A Review of Applications of Nanoceria in Cancer |
| title_sort | review of applications of nanoceria in cancer |
| topic | cerium oxide nanoparticles protective effect sensitizing effect chemotherapy radiotherapy |
| url | http://jmums.mazums.ac.ir/article-1-18223-en.html |
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