Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review
Atrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct relationship exists between AF and altered mitochondrial activity resulting from membrane potential loss, contract...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/535 |
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| author | Antônio da Silva Menezes Júnior Ana Luísa Guedes de França-e-Silva Joyce Monteiro de Oliveira Daniela Melo da Silva |
| author_facet | Antônio da Silva Menezes Júnior Ana Luísa Guedes de França-e-Silva Joyce Monteiro de Oliveira Daniela Melo da Silva |
| author_sort | Antônio da Silva Menezes Júnior |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct relationship exists between AF and altered mitochondrial activity resulting from membrane potential loss, contractile dysfunction, or decreased ATP levels. This review aimed to elucidate the role of mitochondrial oxidative mechanisms in AF pathophysiology, the impact of mitochondrial oxidative stress on AF initiation and perpetuation, and current therapies. This review followed the Preferred Reporting Items for Systematic Reviews and the Meta-Analysis Extension for Scoping Reviews. PubMed, Excerpta Medica Database, and Scopus were explored until June 2023 using “MESH terms”. Bibliographic references to relevant papers were also included. Oxidative stress is an imbalance that causes cellular damage from excessive oxidation, resulting in conditions such as AF. An imbalance in reactive oxygen species production and elimination can cause mitochondrial damage, cellular apoptosis, and cardiovascular diseases. Oxidative stress and inflammation are intrinsically linked, and inflammatory pathways are highly correlated with the occurrence of AF. AF is an intricate cardiac condition that requires innovative therapeutic approaches. The involvement of mitochondrial oxidative stress in the pathophysiology of AF introduces novel strategies for clinical treatment. |
| first_indexed | 2024-03-08T15:04:39Z |
| format | Article |
| id | doaj.art-65e0f286ec714272bc34fc332d0a22d5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:04:39Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-65e0f286ec714272bc34fc332d0a22d52024-01-10T14:59:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125153510.3390/ijms25010535Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping ReviewAntônio da Silva Menezes Júnior0Ana Luísa Guedes de França-e-Silva1Joyce Monteiro de Oliveira2Daniela Melo da Silva3Internal Medicine Department, Medicine School, Federal University of Goiás, Goiânia 74605-020, GO, BrazilInternal Medicine Department, Medicine School, Federal University of Goiás, Goiânia 74605-020, GO, BrazilMedicine Department, Medical and Life School, Pontifical Catholic University of Goiás, Avenida Universitária, 1440, Sector Universitario, Goiânia 74605-010, GO, BrazilInternal Medicine Department, Medicine School, Federal University of Goiás, Goiânia 74605-020, GO, BrazilAtrial fibrillation (AF) is a cardiac arrhythmia caused by electrophysiological anomalies in the atrial tissue, tissue degradation, structural abnormalities, and comorbidities. A direct relationship exists between AF and altered mitochondrial activity resulting from membrane potential loss, contractile dysfunction, or decreased ATP levels. This review aimed to elucidate the role of mitochondrial oxidative mechanisms in AF pathophysiology, the impact of mitochondrial oxidative stress on AF initiation and perpetuation, and current therapies. This review followed the Preferred Reporting Items for Systematic Reviews and the Meta-Analysis Extension for Scoping Reviews. PubMed, Excerpta Medica Database, and Scopus were explored until June 2023 using “MESH terms”. Bibliographic references to relevant papers were also included. Oxidative stress is an imbalance that causes cellular damage from excessive oxidation, resulting in conditions such as AF. An imbalance in reactive oxygen species production and elimination can cause mitochondrial damage, cellular apoptosis, and cardiovascular diseases. Oxidative stress and inflammation are intrinsically linked, and inflammatory pathways are highly correlated with the occurrence of AF. AF is an intricate cardiac condition that requires innovative therapeutic approaches. The involvement of mitochondrial oxidative stress in the pathophysiology of AF introduces novel strategies for clinical treatment.https://www.mdpi.com/1422-0067/25/1/535oxidative stressatrial fibrillationmitochondrial dysfunctioninflammationantioxidant drug discovery |
| spellingShingle | Antônio da Silva Menezes Júnior Ana Luísa Guedes de França-e-Silva Joyce Monteiro de Oliveira Daniela Melo da Silva Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review International Journal of Molecular Sciences oxidative stress atrial fibrillation mitochondrial dysfunction inflammation antioxidant drug discovery |
| title | Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review |
| title_full | Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review |
| title_fullStr | Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review |
| title_full_unstemmed | Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review |
| title_short | Developing Pharmacological Therapies for Atrial Fibrillation Targeting Mitochondrial Dysfunction and Oxidative Stress: A Scoping Review |
| title_sort | developing pharmacological therapies for atrial fibrillation targeting mitochondrial dysfunction and oxidative stress a scoping review |
| topic | oxidative stress atrial fibrillation mitochondrial dysfunction inflammation antioxidant drug discovery |
| url | https://www.mdpi.com/1422-0067/25/1/535 |
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