The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania
Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.671913/full |
| _version_ | 1818645588261994496 |
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| author | Tainá Cavalcante Mariana Medina Medeiros Simon Ngao Mule Giuseppe Palmisano Beatriz Simonsen Stolf |
| author_facet | Tainá Cavalcante Mariana Medina Medeiros Simon Ngao Mule Giuseppe Palmisano Beatriz Simonsen Stolf |
| author_sort | Tainá Cavalcante |
| collection | DOAJ |
| description | Carbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens. More than 20 pathogens can synthesize or capture Sias from their hosts and incorporate them into their own glycoconjugates and derivatives. Sialylation of pathogens’ glycoconjugates may be crucial for survival inside the host for numerous reasons. The role of Sias in protozoa such as Trypanosoma and Leishmania was demonstrated in previous studies. This review highlights the importance of Sias in several pathogenic infections, focusing on Leishmania. We describe in detail the contributions of Sias, Siglecs (sialic acid binding Ig-like lectins) and Neuraminidase 1 (NEU 1) in the course of Leishmania infection. A detailed view on the structural and functional diversity of Leishmania-related Sias and host-cell receptors will be provided, as well as the results of functional studies performed with different Leishmania species. |
| first_indexed | 2024-12-17T00:33:08Z |
| format | Article |
| id | doaj.art-65e14870825146c98571d92eab0edb74 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-17T00:33:08Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-65e14870825146c98571d92eab0edb742022-12-21T22:10:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-05-011110.3389/fcimb.2021.671913671913The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on LeishmaniaTainá Cavalcante0Mariana Medina Medeiros1Simon Ngao Mule2Giuseppe Palmisano3Beatriz Simonsen Stolf4Laboratory of Leishmaniasis, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilLaboratory of Leishmaniasis, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilGlycoProteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilGlycoProteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilLaboratory of Leishmaniasis, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, BrazilCarbohydrates or glycans are ubiquitous components of the cell surface which play crucial biological and structural roles. Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens. More than 20 pathogens can synthesize or capture Sias from their hosts and incorporate them into their own glycoconjugates and derivatives. Sialylation of pathogens’ glycoconjugates may be crucial for survival inside the host for numerous reasons. The role of Sias in protozoa such as Trypanosoma and Leishmania was demonstrated in previous studies. This review highlights the importance of Sias in several pathogenic infections, focusing on Leishmania. We describe in detail the contributions of Sias, Siglecs (sialic acid binding Ig-like lectins) and Neuraminidase 1 (NEU 1) in the course of Leishmania infection. A detailed view on the structural and functional diversity of Leishmania-related Sias and host-cell receptors will be provided, as well as the results of functional studies performed with different Leishmania species.https://www.frontiersin.org/articles/10.3389/fcimb.2021.671913/fullLeishmaniasialic acidsinfectionhost-pathogenSiglec |
| spellingShingle | Tainá Cavalcante Mariana Medina Medeiros Simon Ngao Mule Giuseppe Palmisano Beatriz Simonsen Stolf The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania Frontiers in Cellular and Infection Microbiology Leishmania sialic acids infection host-pathogen Siglec |
| title | The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania |
| title_full | The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania |
| title_fullStr | The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania |
| title_full_unstemmed | The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania |
| title_short | The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania |
| title_sort | role of sialic acids in the establishment of infections by pathogens with special focus on leishmania |
| topic | Leishmania sialic acids infection host-pathogen Siglec |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.671913/full |
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