Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review
Gestational trophoblastic neoplasia (GTN) is an uncommon group of pregnancy-related malignancies. Delayed diagnosis is a prognostic factor for worse outcome. GTN is even harder to diagnose if the site of metastasis is uncommon. The reported case is a 27-year-old G2P1A1 woman who presented to our cen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2020-05-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/506329 |
| _version_ | 1818855573283667968 |
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| author | Nida Jareemit Mongkol Benjapibal |
| author_facet | Nida Jareemit Mongkol Benjapibal |
| author_sort | Nida Jareemit |
| collection | DOAJ |
| description | Gestational trophoblastic neoplasia (GTN) is an uncommon group of pregnancy-related malignancies. Delayed diagnosis is a prognostic factor for worse outcome. GTN is even harder to diagnose if the site of metastasis is uncommon. The reported case is a 27-year-old G2P1A1 woman who presented to our center with acute transient generalized tonic-clonic seizure. She had developed hemoptysis for the 2 preceding weeks, which had been treated as pneumonia. She had then noticed multiple gum lesions and vaginal spotting 1 week before her presentation. Her serum β-human chorionic gonadotropin level was 77,474 IU/L without evidence of pregnancy. She was diagnosed with GTN with lung, brain, and gum metastases. The patient was staged as IV with a World Health Organization prognostic score of 14. Etoposide, methotrexate, actinomycin D alternating with cyclophosphamide, and vincristine weekly (EMACO) were given. The gum lesions disappeared after 2 cycles of the multiagent chemotherapy, and complete remission was achieved after 8 cycles. This case study will increase awareness of uncommon metastatic sites of GTN. Any associated vaginal bleeding should be considered a clue to metastatic GTN. |
| first_indexed | 2024-12-19T08:10:45Z |
| format | Article |
| id | doaj.art-65e2999c57a8487db81282e5bc93659e |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-19T08:10:45Z |
| publishDate | 2020-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-65e2999c57a8487db81282e5bc93659e2022-12-21T20:29:37ZengKarger PublishersCase Reports in Oncology1662-65752020-05-0113248549010.1159/000506329506329Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature ReviewNida JareemitMongkol BenjapibalGestational trophoblastic neoplasia (GTN) is an uncommon group of pregnancy-related malignancies. Delayed diagnosis is a prognostic factor for worse outcome. GTN is even harder to diagnose if the site of metastasis is uncommon. The reported case is a 27-year-old G2P1A1 woman who presented to our center with acute transient generalized tonic-clonic seizure. She had developed hemoptysis for the 2 preceding weeks, which had been treated as pneumonia. She had then noticed multiple gum lesions and vaginal spotting 1 week before her presentation. Her serum β-human chorionic gonadotropin level was 77,474 IU/L without evidence of pregnancy. She was diagnosed with GTN with lung, brain, and gum metastases. The patient was staged as IV with a World Health Organization prognostic score of 14. Etoposide, methotrexate, actinomycin D alternating with cyclophosphamide, and vincristine weekly (EMACO) were given. The gum lesions disappeared after 2 cycles of the multiagent chemotherapy, and complete remission was achieved after 8 cycles. This case study will increase awareness of uncommon metastatic sites of GTN. Any associated vaginal bleeding should be considered a clue to metastatic GTN.https://www.karger.com/Article/FullText/506329gestational trophoblastic neoplasiagum metastasishigh risk |
| spellingShingle | Nida Jareemit Mongkol Benjapibal Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review Case Reports in Oncology gestational trophoblastic neoplasia gum metastasis high risk |
| title | Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review |
| title_full | Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review |
| title_fullStr | Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review |
| title_full_unstemmed | Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review |
| title_short | Gestational Trophoblastic Neoplasia with Gum Metastasis: A Case Study and Literature Review |
| title_sort | gestational trophoblastic neoplasia with gum metastasis a case study and literature review |
| topic | gestational trophoblastic neoplasia gum metastasis high risk |
| url | https://www.karger.com/Article/FullText/506329 |
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