Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia?
Abstract Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of cerebral blood flow (CBF) autoregulation. Au...
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15376 |
| _version_ | 1818529402788511744 |
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| author | Zoltan Nemeth Joey P. Granger Michael J. Ryan Heather A. Drummond |
| author_facet | Zoltan Nemeth Joey P. Granger Michael J. Ryan Heather A. Drummond |
| author_sort | Zoltan Nemeth |
| collection | DOAJ |
| description | Abstract Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of cerebral blood flow (CBF) autoregulation. Autoregulation is the maintenance of CBF to meet local demands with changes in perfusion pressure. When perfusion pressure rises, vasoconstriction of cerebral arteries and arterioles maintains flow and prevents the transfer of higher systemic pressure to downstream microvasculature. In the face of concurrent hypertension, loss of autoregulatory control exposes small delicate microvessels to injury from elevated systemic blood pressure. While placental ischemia is considered the initiating event in the preeclamptic cascade, the factor(s) mediating cerebrovascular dysfunction are poorly understood. Elevated plasma proinflammatory cytokines, such as tumor necrosis factor α (TNF‐α) and interleukin‐17 (IL‐17), are potential mediators of autoregulatory loss. Impaired CBF responses to increases in systemic pressure are attributed to the impaired pressure‐induced (myogenic) constriction of small cerebral arteries and arterioles in PE. Myogenic vasoconstriction is initiated by pressure‐induced vascular smooth muscle cell (VSMC) stretch. Recent studies from our laboratory group indicate that proinflammatory cytokines impair the myogenic mechanism of CBF autoregulation via inhibition of vascular degenerin proteins, putative mediators of myogenic constriction in VSMCs. This brief review links studies showing the effect of proinflammatory cytokines on degenerin expression and CBF autoregulation to the pathological cerebral consequences of preeclampsia. |
| first_indexed | 2024-12-11T17:06:25Z |
| format | Article |
| id | doaj.art-65e338eb5e304c10846c3ac339406854 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-11T17:06:25Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-65e338eb5e304c10846c3ac3394068542022-12-22T00:57:40ZengWileyPhysiological Reports2051-817X2022-07-011013n/an/a10.14814/phy2.15376Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia?Zoltan Nemeth0Joey P. Granger1Michael J. Ryan2Heather A. Drummond3Department of Physiology and Biophysics University of Mississippi Medical Center Jackson Mississippi USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson Mississippi USADepartment of Pharmacology, Physiology and Neuroscience University of South Carolina School of Medicine Columbia South Carolina USADepartment of Physiology and Biophysics University of Mississippi Medical Center Jackson Mississippi USAAbstract Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of cerebral blood flow (CBF) autoregulation. Autoregulation is the maintenance of CBF to meet local demands with changes in perfusion pressure. When perfusion pressure rises, vasoconstriction of cerebral arteries and arterioles maintains flow and prevents the transfer of higher systemic pressure to downstream microvasculature. In the face of concurrent hypertension, loss of autoregulatory control exposes small delicate microvessels to injury from elevated systemic blood pressure. While placental ischemia is considered the initiating event in the preeclamptic cascade, the factor(s) mediating cerebrovascular dysfunction are poorly understood. Elevated plasma proinflammatory cytokines, such as tumor necrosis factor α (TNF‐α) and interleukin‐17 (IL‐17), are potential mediators of autoregulatory loss. Impaired CBF responses to increases in systemic pressure are attributed to the impaired pressure‐induced (myogenic) constriction of small cerebral arteries and arterioles in PE. Myogenic vasoconstriction is initiated by pressure‐induced vascular smooth muscle cell (VSMC) stretch. Recent studies from our laboratory group indicate that proinflammatory cytokines impair the myogenic mechanism of CBF autoregulation via inhibition of vascular degenerin proteins, putative mediators of myogenic constriction in VSMCs. This brief review links studies showing the effect of proinflammatory cytokines on degenerin expression and CBF autoregulation to the pathological cerebral consequences of preeclampsia.https://doi.org/10.14814/phy2.15376autoregulationcerebral blood flowmyogenic toneTNF‐αβENaC |
| spellingShingle | Zoltan Nemeth Joey P. Granger Michael J. Ryan Heather A. Drummond Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? Physiological Reports autoregulation cerebral blood flow myogenic tone TNF‐α βENaC |
| title | Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? |
| title_full | Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? |
| title_fullStr | Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? |
| title_full_unstemmed | Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? |
| title_short | Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? |
| title_sort | is there a role of proinflammatory cytokines on degenerin mediated cerebrovascular function in preeclampsia |
| topic | autoregulation cerebral blood flow myogenic tone TNF‐α βENaC |
| url | https://doi.org/10.14814/phy2.15376 |
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