Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor
The EGFR signaling pathway plays an important role in the occurrence and development of many malignant tumors. It has become a hot spot in the treatment of advanced cancer. At present, the small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been shown to advance...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2016-01-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2016-0056 |
| _version_ | 1819106621624680448 |
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| author | Zhang Lingling Zhang Xiaoxue Zhao Liang |
| author_facet | Zhang Lingling Zhang Xiaoxue Zhao Liang |
| author_sort | Zhang Lingling |
| collection | DOAJ |
| description | The EGFR signaling pathway plays an important role in the occurrence and development of many malignant tumors. It has become a hot spot in the treatment of advanced cancer. At present, the small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been shown to advanced non-small-cell lung cancer (NSCLC), has a marked drug resistance or has developed one. The EGFR signaling pathway regulates a variety of cellular functions, and its drug resistance may be related to a number of signal transduction pathways, including drug resistance mutations, structural activation, downstream signaling pathway activation and VEGF expression changes, and so on. In this paper, we review the production mechanism of EGFR-TKI drug resistance. |
| first_indexed | 2024-12-22T02:41:03Z |
| format | Article |
| id | doaj.art-65e3c6db30444c13af9af065439d01f4 |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-12-22T02:41:03Z |
| publishDate | 2016-01-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-65e3c6db30444c13af9af065439d01f42022-12-21T18:41:38ZengDe GruyterOpen Life Sciences2391-54122016-01-0111142743110.1515/biol-2016-0056biol-2016-0056Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitorZhang Lingling0Zhang Xiaoxue1Zhao Liang2Department of Oncology, Binzhou People's Hospital, Binzhou, 256610, ChinaDepartment of Oncology, Qingdao Hiser Hospital, Qingdao, 266000, ChinaDepartment of Oncology, Binzhou People's Hospital, Binzhou, 256610, ChinaThe EGFR signaling pathway plays an important role in the occurrence and development of many malignant tumors. It has become a hot spot in the treatment of advanced cancer. At present, the small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has been shown to advanced non-small-cell lung cancer (NSCLC), has a marked drug resistance or has developed one. The EGFR signaling pathway regulates a variety of cellular functions, and its drug resistance may be related to a number of signal transduction pathways, including drug resistance mutations, structural activation, downstream signaling pathway activation and VEGF expression changes, and so on. In this paper, we review the production mechanism of EGFR-TKI drug resistance.https://doi.org/10.1515/biol-2016-0056non-small-cell lung cancer (nsclc)epidermal growth factor receptor (egfr)tyrosine kinase inhibitor |
| spellingShingle | Zhang Lingling Zhang Xiaoxue Zhao Liang Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor Open Life Sciences non-small-cell lung cancer (nsclc) epidermal growth factor receptor (egfr) tyrosine kinase inhibitor |
| title | Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| title_full | Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| title_fullStr | Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| title_full_unstemmed | Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| title_short | Progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| title_sort | progress toward resistance mechanism to epidermal growth factor receptor tyrosine kinase inhibitor |
| topic | non-small-cell lung cancer (nsclc) epidermal growth factor receptor (egfr) tyrosine kinase inhibitor |
| url | https://doi.org/10.1515/biol-2016-0056 |
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