Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells
In this work, a refluxing method is used to prepare nanoparticles of zinc oxide (ZnO NPS) and zinc oxide /silver chloride nanocomposites (ZnO/AgCl NCS). The structural properties of nanocrystals are studied by Atomic Force Microscope (AFM), X-Ray Diffraction (XRD), and Field Emission Scanning Electr...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2023-02-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/ijc/article/view/76872 |
| _version_ | 1797845196803670016 |
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| author | Fattima Al-Zahra Gabar Gassim Ali Jabbar Jasim Makkawi |
| author_facet | Fattima Al-Zahra Gabar Gassim Ali Jabbar Jasim Makkawi |
| author_sort | Fattima Al-Zahra Gabar Gassim |
| collection | DOAJ |
| description | In this work, a refluxing method is used to prepare nanoparticles of zinc oxide (ZnO NPS) and zinc oxide /silver chloride nanocomposites (ZnO/AgCl NCS). The structural properties of nanocrystals are studied by Atomic Force Microscope (AFM), X-Ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM) to determine the average crystal size, morphology, particle size and average grain size of nanocrystals. The results of anticancer efficiency of ZnO NPs and ZnO/AgCl NCs show cytotoxic activity against five human cancer cells, namely hepatocellular carcinoma, rhabdomyosarcoma (RD), colorectal carcinoma (HCT116), mammary gland (MCF-7), and epidermoid carcinoma (Hep2) compared against doxorubicin. The anticancer mechanism of pure and nanocomposites ZnO are suggested according to the release of Zn+2 and the production of reactive oxidation species (ROS) and the effect of these species on cancer inhibition. |
| first_indexed | 2024-04-09T17:34:55Z |
| format | Article |
| id | doaj.art-65e43cde575d450394b153615490cdd6 |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-04-09T17:34:55Z |
| publishDate | 2023-02-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-65e43cde575d450394b153615490cdd62023-04-18T01:55:50ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782023-02-0123233334010.22146/ijc.7687233250Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer CellsFattima Al-Zahra Gabar Gassim0Ali Jabbar Jasim Makkawi1Department of Pharmaceuticals, College of Pharmacy, University of Babylon, Hilla 51002, IraqDepartment of Chemistry, College of Science, University of Babylon, Ministry of Education, Hilla 51002, IraqIn this work, a refluxing method is used to prepare nanoparticles of zinc oxide (ZnO NPS) and zinc oxide /silver chloride nanocomposites (ZnO/AgCl NCS). The structural properties of nanocrystals are studied by Atomic Force Microscope (AFM), X-Ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM) to determine the average crystal size, morphology, particle size and average grain size of nanocrystals. The results of anticancer efficiency of ZnO NPs and ZnO/AgCl NCs show cytotoxic activity against five human cancer cells, namely hepatocellular carcinoma, rhabdomyosarcoma (RD), colorectal carcinoma (HCT116), mammary gland (MCF-7), and epidermoid carcinoma (Hep2) compared against doxorubicin. The anticancer mechanism of pure and nanocomposites ZnO are suggested according to the release of Zn+2 and the production of reactive oxidation species (ROS) and the effect of these species on cancer inhibition.https://jurnal.ugm.ac.id/ijc/article/view/76872zno nanoparticlesthe anticancer activity of nanoparticleszno/agcl nanocomposites |
| spellingShingle | Fattima Al-Zahra Gabar Gassim Ali Jabbar Jasim Makkawi Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells Indonesian Journal of Chemistry zno nanoparticles the anticancer activity of nanoparticles zno/agcl nanocomposites |
| title | Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells |
| title_full | Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells |
| title_fullStr | Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells |
| title_full_unstemmed | Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells |
| title_short | Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells |
| title_sort | anticancer activity of synthesized zno and zno agcl nanocomposites against five human cancer cells |
| topic | zno nanoparticles the anticancer activity of nanoparticles zno/agcl nanocomposites |
| url | https://jurnal.ugm.ac.id/ijc/article/view/76872 |
| work_keys_str_mv | AT fattimaalzahragabargassim anticanceractivityofsynthesizedznoandznoagclnanocompositesagainstfivehumancancercells AT alijabbarjasimmakkawi anticanceractivityofsynthesizedznoandznoagclnanocompositesagainstfivehumancancercells |