Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate

Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate

Abstract Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells. Heparan sulfate interacts with the receptor binding domain of SARS-CoV-2 spike glycoprotein, and blocking this interaction can decr...

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Bibliographic Details
Main Authors: Yulia Kiyan, Anna Schultalbers, Ekaterina Chernobrivaia, Sergey Tkachuk, Song Rong, Nelli Shushakova, Hermann Haller
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20973-3

Internet

https://doi.org/10.1038/s41598-022-20973-3

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