Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty
Background: Development of endophthalmitis during cataract surgery is one of the most severe complications and it may also result in blindness and globe loss. Aims: To evaluate the effect of an ophthalmic cefuroxime solution (Aprokam®) that is prophylactically used in phacoemulsification surgery pe...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2018-03-01
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| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php?lang=en&id=1956 |
| _version_ | 1797915298167259136 |
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| author | Mustafa Erdoğan Cicik Cezmi Doğan Osman Şevki Arslan |
| author_facet | Mustafa Erdoğan Cicik Cezmi Doğan Osman Şevki Arslan |
| author_sort | Mustafa Erdoğan Cicik |
| collection | DOAJ |
| description | Background: Development of endophthalmitis during cataract surgery is one of the most severe complications and it may also result in blindness and globe loss.
Aims: To evaluate the effect of an ophthalmic cefuroxime solution (Aprokam®) that is prophylactically used in phacoemulsification surgery performed due to cataract that eventually occurs in patients with or without penetrating keratoplasty.
Study Design: Case-control study.
Methods: In this retrospective study, patients who had undergone penetrating keratoplasty and for whom phacoemulsification surgery was performed due to cataract and an intracameral ophthalmic cefuroxime solution (Aprokam®) was administered for prophylaxis were evaluated in comparison with patients with cataract without keratoplasty. The following parameters were evaluated: postoperative anterior chamber reaction, intraocular pressure, best corrected visual acuity, corneal endothelial cell density, and central corneal thickness alterations.
Results: A total of 42 patients (18 males, 24 females) with keratoplasty and 42 patients (17 males, 25 females) without keratoplasty were included in this study. An increase in visual acuity was observed in all the patients after cataract surgery (p<0.001). The mean corneal endothelial cell densitys were determined to be 2437.20±148.5 cells/mm2 preoperatively in the study group and 2807.1±152.4 cells/mm2 preoperatively in the control group. The mean corneal endothelial cell densitys were determined to be 2103.85±196.5 cells/mm2 after the first postoperative month (p<0.001) in the study group and 2755.92±182.7 cells/mm2 in the control group (p=0.17). The mean central corneal thickness in the study group were 565.78±11.5 μm preoperatively and 584.65±12.7 μm after the first postoperative month (p<0.001). No difference was observed in the control group in terms of preoperative and postoperative central corneal thickness and endothelial cell density. There was no significant difference between the groups in terms of the intraocular pressure, anterior chamber reaction.
Conclusion: There was no significant effect of the prophylactic intracameral use of ophthalmic cefuroxime solution (Aprokam®) on the endothelial cells which was used in patients with keratoplasty for whom cataract surgery was performed. |
| first_indexed | 2024-04-10T12:39:37Z |
| format | Article |
| id | doaj.art-65e53fdfa4794e2ea201972e91c1f367 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T12:39:37Z |
| publishDate | 2018-03-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-65e53fdfa4794e2ea201972e91c1f3672023-02-15T16:14:22ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312018-03-0135218118510.4274/balkanmedj.2017.1493Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with KeratoplastyMustafa Erdoğan Cicik0Cezmi Doğan1Osman Şevki Arslan2Department of Ophthalmology, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, TurkeyDepartment of Ophthalmology, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, TurkeyDepartment of Ophthalmology, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, TurkeyBackground: Development of endophthalmitis during cataract surgery is one of the most severe complications and it may also result in blindness and globe loss. Aims: To evaluate the effect of an ophthalmic cefuroxime solution (Aprokam®) that is prophylactically used in phacoemulsification surgery performed due to cataract that eventually occurs in patients with or without penetrating keratoplasty. Study Design: Case-control study. Methods: In this retrospective study, patients who had undergone penetrating keratoplasty and for whom phacoemulsification surgery was performed due to cataract and an intracameral ophthalmic cefuroxime solution (Aprokam®) was administered for prophylaxis were evaluated in comparison with patients with cataract without keratoplasty. The following parameters were evaluated: postoperative anterior chamber reaction, intraocular pressure, best corrected visual acuity, corneal endothelial cell density, and central corneal thickness alterations. Results: A total of 42 patients (18 males, 24 females) with keratoplasty and 42 patients (17 males, 25 females) without keratoplasty were included in this study. An increase in visual acuity was observed in all the patients after cataract surgery (p<0.001). The mean corneal endothelial cell densitys were determined to be 2437.20±148.5 cells/mm2 preoperatively in the study group and 2807.1±152.4 cells/mm2 preoperatively in the control group. The mean corneal endothelial cell densitys were determined to be 2103.85±196.5 cells/mm2 after the first postoperative month (p<0.001) in the study group and 2755.92±182.7 cells/mm2 in the control group (p=0.17). The mean central corneal thickness in the study group were 565.78±11.5 μm preoperatively and 584.65±12.7 μm after the first postoperative month (p<0.001). No difference was observed in the control group in terms of preoperative and postoperative central corneal thickness and endothelial cell density. There was no significant difference between the groups in terms of the intraocular pressure, anterior chamber reaction. Conclusion: There was no significant effect of the prophylactic intracameral use of ophthalmic cefuroxime solution (Aprokam®) on the endothelial cells which was used in patients with keratoplasty for whom cataract surgery was performed.http://balkanmedicaljournal.org/text.php?lang=en&id=1956Aprokamcefuroximecataractkeratoplastyprophylaxis |
| spellingShingle | Mustafa Erdoğan Cicik Cezmi Doğan Osman Şevki Arslan Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty Balkan Medical Journal Aprokam cefuroxime cataract keratoplasty prophylaxis |
| title | Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty |
| title_full | Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty |
| title_fullStr | Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty |
| title_full_unstemmed | Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty |
| title_short | Effect of Intracameral Ophthalmic Cefuroxime Solution (Aprokam®) in the Prophylaxis of Cataract Surgery in Patients with Keratoplasty |
| title_sort | effect of intracameral ophthalmic cefuroxime solution aprokam r in the prophylaxis of cataract surgery in patients with keratoplasty |
| topic | Aprokam cefuroxime cataract keratoplasty prophylaxis |
| url | http://balkanmedicaljournal.org/text.php?lang=en&id=1956 |
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