Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells
Metabolic reprogramming is associated with cancer initiation, progression and resistance to therapy. Here, the authors show that metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation is associated with cancer-cell platinum-based chemotherapy resistance.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32101-w |
| _version_ | 1798038051256008704 |
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| author | Yuying Tan Junjie Li Guangyuan Zhao Kai-Chih Huang Horacio Cardenas Yinu Wang Daniela Matei Ji-Xin Cheng |
| author_facet | Yuying Tan Junjie Li Guangyuan Zhao Kai-Chih Huang Horacio Cardenas Yinu Wang Daniela Matei Ji-Xin Cheng |
| author_sort | Yuying Tan |
| collection | DOAJ |
| description | Metabolic reprogramming is associated with cancer initiation, progression and resistance to therapy. Here, the authors show that metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation is associated with cancer-cell platinum-based chemotherapy resistance. |
| first_indexed | 2024-04-11T21:34:56Z |
| format | Article |
| id | doaj.art-65e7d80db4764219a65df7b321e8f777 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T21:34:56Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-65e7d80db4764219a65df7b321e8f7772022-12-22T04:01:48ZengNature PortfolioNature Communications2041-17232022-08-0113111610.1038/s41467-022-32101-wMetabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cellsYuying Tan0Junjie Li1Guangyuan Zhao2Kai-Chih Huang3Horacio Cardenas4Yinu Wang5Daniela Matei6Ji-Xin Cheng7Biomedical Engineering, Boston UniversityElectrical and Computer Engineering, Boston UniversityDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern UniversityBiomedical Engineering, Boston UniversityDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern UniversityDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern UniversityDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern UniversityBiomedical Engineering, Boston UniversityMetabolic reprogramming is associated with cancer initiation, progression and resistance to therapy. Here, the authors show that metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation is associated with cancer-cell platinum-based chemotherapy resistance.https://doi.org/10.1038/s41467-022-32101-w |
| spellingShingle | Yuying Tan Junjie Li Guangyuan Zhao Kai-Chih Huang Horacio Cardenas Yinu Wang Daniela Matei Ji-Xin Cheng Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells Nature Communications |
| title | Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells |
| title_full | Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells |
| title_fullStr | Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells |
| title_full_unstemmed | Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells |
| title_short | Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells |
| title_sort | metabolic reprogramming from glycolysis to fatty acid uptake and beta oxidation in platinum resistant cancer cells |
| url | https://doi.org/10.1038/s41467-022-32101-w |
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