Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus
Objective: To compare Serum gamma-glutamyl transferase and serum C-reactive protein as biomarker of oxidative stress in patients of type 2 Diabetes Mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: The study was conducted at Armed Forces Institute of Patholog...
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| Format: | Article |
| Language: | English |
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Riphah International University, Islamabad
2023-06-01
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| Series: | Journal of Islamic International Medical College |
| Subjects: | |
| Online Access: | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1570 |
| _version_ | 1797794635737726976 |
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| author | Dr. Ammar ul Hassan Zujaja Hina Haroon Sobia Irum Kirmani Muhammad Anwar Muhammad Younas Muhammad Usman Munir |
| author_facet | Dr. Ammar ul Hassan Zujaja Hina Haroon Sobia Irum Kirmani Muhammad Anwar Muhammad Younas Muhammad Usman Munir |
| author_sort | Dr. Ammar ul Hassan |
| collection | DOAJ |
| description | Objective: To compare Serum gamma-glutamyl transferase and serum C-reactive protein as biomarker of oxidative stress in patients of type 2 Diabetes Mellitus.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: The study was conducted at Armed Forces Institute of Pathology, department of Chemical Pathology and Endocrinology Rawalpindi. The duration of study was 6 months i.e., 17 Nov 2021 – 17 May 2022 after approval from Institutional Review Board FC-CHP21-12/Read-IRB/22/846.
Materials and Methods: An analytical, cross-sectional research was carried out at Armed Forces Institute of Pathology Rawalpindi. An overall 300 diabetic patients were included between ages of 45 – 65 years. Group I had 100 nondiabetic individuals of 45 – 65 years of age with HbA1c < 5.7 %. Group II and III included 100 patients each of DM of matched age with HbA1c 6.5 – 7 % and greater than 7 % respectively, without any other chronic disease. Serum gamma-glutamyl transferase, HbA1c, Serum C-Reactive Protein were analyzed. Moreover,
some more biochemical investigations such as serum liver enzymes were measured to rule out any liver disease. One-way ANOVA was followed up by post-hoc Tukey analysis for intergroup comparison.
Results: Mean serum gamma-glutamyl transferase levels were markedly increased in group III patients followed by group II and normal in group I. The mean of serum gamma-glutamyl transferase in group I was
(9.38+4.05U/l), group II (34.27+15.07 U/l) and group III (47.08+20.56 U/l). The mean of Serum C-Reactive Protein in group I was (11+6.02 mg/l), group II (62.07+ 26.94 mg/l) and group III (107.73+57.03 mg/l). Pearson
correlation revealed prominent positive correlation between HbA1c, serum gamma-glutamyl transferase and Serum C-Reactive Protein with r value of serum gamma-glutamyl transferase (0.838367) and Serum C-Reactive Protein (0.684722). One-way ANOVA and post-hoc Tukey analysis had p value of < 0.05 which was statistically
significant.
Conclusion: Serum gamma-glutamyl transferase is better marker of oxidative stress in patients of type 2 diabetes mellitus as compared to Serum C-Reactive Protein. The r value of serum gamma-glutamyl transferase is (0.838367) and Serum C-Reactive Protein is (0.684722) indicating strong positive correlation of serum gamma-glutamyl transferase with HbA1c. Therefore, Serum gamma-glutamyl transferase can be used for the prevention and monitoring of complications of type 2 Diabetes Mellitus. |
| first_indexed | 2024-03-13T03:05:45Z |
| format | Article |
| id | doaj.art-65e8064c7cd84242862412973608b1d2 |
| institution | Directory Open Access Journal |
| issn | 1815-4018 2410-5422 |
| language | English |
| last_indexed | 2024-03-13T03:05:45Z |
| publishDate | 2023-06-01 |
| publisher | Riphah International University, Islamabad |
| record_format | Article |
| series | Journal of Islamic International Medical College |
| spelling | doaj.art-65e8064c7cd84242862412973608b1d22023-06-27T05:09:04ZengRiphah International University, IslamabadJournal of Islamic International Medical College1815-40182410-54222023-06-011829397https://doi.org/10.57234/jiimc.june23.1570Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes MellitusDr. Ammar ul Hassan0Zujaja Hina Haroon1Sobia Irum Kirmani2Muhammad Anwar3Muhammad Younas4Muhammad Usman Munir5Armed Forces Institute of Pathology, RawalpindiArmed Forces Institute of Pathology, RawalpindiArmed Forces Institute of Pathology, RawalpindiArmed Forces Institute of Pathology, RawalpindiArmed Forces Institute of Pathology, RawalpindiArmed Forces Institute of Pathology, RawalpindiObjective: To compare Serum gamma-glutamyl transferase and serum C-reactive protein as biomarker of oxidative stress in patients of type 2 Diabetes Mellitus. Study Design: Comparative cross-sectional study. Place and Duration of Study: The study was conducted at Armed Forces Institute of Pathology, department of Chemical Pathology and Endocrinology Rawalpindi. The duration of study was 6 months i.e., 17 Nov 2021 – 17 May 2022 after approval from Institutional Review Board FC-CHP21-12/Read-IRB/22/846. Materials and Methods: An analytical, cross-sectional research was carried out at Armed Forces Institute of Pathology Rawalpindi. An overall 300 diabetic patients were included between ages of 45 – 65 years. Group I had 100 nondiabetic individuals of 45 – 65 years of age with HbA1c < 5.7 %. Group II and III included 100 patients each of DM of matched age with HbA1c 6.5 – 7 % and greater than 7 % respectively, without any other chronic disease. Serum gamma-glutamyl transferase, HbA1c, Serum C-Reactive Protein were analyzed. Moreover, some more biochemical investigations such as serum liver enzymes were measured to rule out any liver disease. One-way ANOVA was followed up by post-hoc Tukey analysis for intergroup comparison. Results: Mean serum gamma-glutamyl transferase levels were markedly increased in group III patients followed by group II and normal in group I. The mean of serum gamma-glutamyl transferase in group I was (9.38+4.05U/l), group II (34.27+15.07 U/l) and group III (47.08+20.56 U/l). The mean of Serum C-Reactive Protein in group I was (11+6.02 mg/l), group II (62.07+ 26.94 mg/l) and group III (107.73+57.03 mg/l). Pearson correlation revealed prominent positive correlation between HbA1c, serum gamma-glutamyl transferase and Serum C-Reactive Protein with r value of serum gamma-glutamyl transferase (0.838367) and Serum C-Reactive Protein (0.684722). One-way ANOVA and post-hoc Tukey analysis had p value of < 0.05 which was statistically significant. Conclusion: Serum gamma-glutamyl transferase is better marker of oxidative stress in patients of type 2 diabetes mellitus as compared to Serum C-Reactive Protein. The r value of serum gamma-glutamyl transferase is (0.838367) and Serum C-Reactive Protein is (0.684722) indicating strong positive correlation of serum gamma-glutamyl transferase with HbA1c. Therefore, Serum gamma-glutamyl transferase can be used for the prevention and monitoring of complications of type 2 Diabetes Mellitus.https://journals.riphah.edu.pk/index.php/jiimc/article/view/1570armed forces institute of pathology (afip)c reactive protein (crp)diabetes mellitus (dm)gamma glutamyl transferase (ggt) |
| spellingShingle | Dr. Ammar ul Hassan Zujaja Hina Haroon Sobia Irum Kirmani Muhammad Anwar Muhammad Younas Muhammad Usman Munir Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus Journal of Islamic International Medical College armed forces institute of pathology (afip) c reactive protein (crp) diabetes mellitus (dm) gamma glutamyl transferase (ggt) |
| title | Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus |
| title_full | Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus |
| title_fullStr | Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus |
| title_full_unstemmed | Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus |
| title_short | Association of Serum Gamma-Glutamyl Transferase and C-Reactive Protein as a Biomarkers of Oxidative Stress in Patients of Type 2 Diabetes Mellitus |
| title_sort | association of serum gamma glutamyl transferase and c reactive protein as a biomarkers of oxidative stress in patients of type 2 diabetes mellitus |
| topic | armed forces institute of pathology (afip) c reactive protein (crp) diabetes mellitus (dm) gamma glutamyl transferase (ggt) |
| url | https://journals.riphah.edu.pk/index.php/jiimc/article/view/1570 |
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