Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study
Background: Global breast cancer incidence is increasing at an annual rate of 3·1%. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%). However, the data from different parts of India are still lacking and the study w...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Family Medicine and Primary Care |
| Subjects: | |
| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=9;spage=1923;epage=1930;aulast=Srivastava |
| _version_ | 1797645640614805504 |
|---|---|
| author | Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain |
| author_facet | Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain |
| author_sort | Niraj Kumar Srivastava |
| collection | DOAJ |
| description | Background: Global breast cancer incidence is increasing at an annual rate of 3·1%. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%). However, the data from different parts of India are still lacking and the study was conducted to assess the burden of disease at tertiary referral centers in central India. Material and Methods: Retrospective record analysis (June 2013–June 2017) of data from outdoor clinics and pathology reports. The patients aged <15 yrs, nonresidence of Chhattisgarh, and diagnosed outside the study period were excluded. The triple assessment was used to diagnose all breast lumps (sensitivity 99%). Results: Eighty patients were diagnosed having breast carcinoma. The mean age for breast cancer was 39 ± 3.028 years (ranged 31–50 years). Twenty patients had locally advanced breast carcinoma. The predominant religion was Hindu 55.00%. The referral pathway to seek medical care for breast cancer was via a gynecologist in 40% (32/80). Familial breast cancers were in 0.03% (3/80) of patients. None breast cancer patients have previous histology-proven benign breast disease. The mean size of the breast cancer lump was 3.56 cm (ranged 1.0–11.0 cm). Overlying skin ulceration (n = 2), skin infiltration/peau-d'-orange (n = 2), skin tethering (n = 4), and bloody nipple discharge were found in one patient. Breast cancer was diagnosed during lactation (postnatal period) in one patient. The maximum number of patients have tumor size >5 cm (72.6%). Immunohistochemistry and pathological analysis was done on core biopsy (n = 20) and surgical procedure (n = 60). Modified radical mastectomy was done in 52, breast conservative surgery with Sentinal Lymph node biopsy and axillary lymph node dissection in 6, and toilet mastectomy in two patients. The predominant tumors were solid (n = 79/80), with both solid and cystic types (1/80). The solid and cystic lesion on FNAC was of C3b type, and an excision biopsy revealed medullary carcinoma of the breast. Invasive ductal carcinoma-no special type (IDC-NST) was observed to be the most common histopathologic type (n = 70/80), followed by medullary carcinoma (n = 2), metaplastic carcinoma (n = 1), papillary carcinoma (n = 4), Paget disease with DCIS (n = 1), mucinous carcinoma (n = 1), invasive lobular carcinoma (n = 1). One male patient with breast cancer and two female patient having bilateral breast cancer also have IDC-NST.Scarff Bloom Richardson Grade was predominantly graded 2 in 46.25% (37/80) of breast cancer patients (Grade 1 = 9, Grade 2 = 37, Grade 3 = 34). Lymphovascular (LVI) and perineural invasion (PNI) were predominantly without LVI and PVI. (Lymphovascular present and perineural invasion present = 4, Lymphovascular present and perineural invasion absent = 32, Lymphovascular absent and perineural invasion absent = 42, Lymphovascular absent and perineural invasion present = 2). Histological examination of axillary lymph nodes showed the presence of malignant cells in all. Triple-negative breast carcinoma was 26.58% (21/79). Most breast cancer presented at stage II A = 37.5% (30/80) and II B = 28.7% (23/80) of the AJCC staging system. Conclusion: The clinico-epidemio and histological profile of breast cancer in Chhattisgarh is similar to other parts of India. Scarff Bloom Richardson Grade was predominantly grade 2 in 46.25% (37/80) contrary to Grade III (70%) in other series from India. |
| first_indexed | 2024-03-11T14:49:41Z |
| format | Article |
| id | doaj.art-65e8c19baf314ea095859456e718fab1 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-03-11T14:49:41Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-65e8c19baf314ea095859456e718fab12023-10-30T09:46:32ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632023-01-011291923193010.4103/jfmpc.jfmpc_2315_22Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based studyNiraj Kumar SrivastavaSunita SinghDebajyoti MohantyNughat HussainBackground: Global breast cancer incidence is increasing at an annual rate of 3·1%. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%). However, the data from different parts of India are still lacking and the study was conducted to assess the burden of disease at tertiary referral centers in central India. Material and Methods: Retrospective record analysis (June 2013–June 2017) of data from outdoor clinics and pathology reports. The patients aged <15 yrs, nonresidence of Chhattisgarh, and diagnosed outside the study period were excluded. The triple assessment was used to diagnose all breast lumps (sensitivity 99%). Results: Eighty patients were diagnosed having breast carcinoma. The mean age for breast cancer was 39 ± 3.028 years (ranged 31–50 years). Twenty patients had locally advanced breast carcinoma. The predominant religion was Hindu 55.00%. The referral pathway to seek medical care for breast cancer was via a gynecologist in 40% (32/80). Familial breast cancers were in 0.03% (3/80) of patients. None breast cancer patients have previous histology-proven benign breast disease. The mean size of the breast cancer lump was 3.56 cm (ranged 1.0–11.0 cm). Overlying skin ulceration (n = 2), skin infiltration/peau-d'-orange (n = 2), skin tethering (n = 4), and bloody nipple discharge were found in one patient. Breast cancer was diagnosed during lactation (postnatal period) in one patient. The maximum number of patients have tumor size >5 cm (72.6%). Immunohistochemistry and pathological analysis was done on core biopsy (n = 20) and surgical procedure (n = 60). Modified radical mastectomy was done in 52, breast conservative surgery with Sentinal Lymph node biopsy and axillary lymph node dissection in 6, and toilet mastectomy in two patients. The predominant tumors were solid (n = 79/80), with both solid and cystic types (1/80). The solid and cystic lesion on FNAC was of C3b type, and an excision biopsy revealed medullary carcinoma of the breast. Invasive ductal carcinoma-no special type (IDC-NST) was observed to be the most common histopathologic type (n = 70/80), followed by medullary carcinoma (n = 2), metaplastic carcinoma (n = 1), papillary carcinoma (n = 4), Paget disease with DCIS (n = 1), mucinous carcinoma (n = 1), invasive lobular carcinoma (n = 1). One male patient with breast cancer and two female patient having bilateral breast cancer also have IDC-NST.Scarff Bloom Richardson Grade was predominantly graded 2 in 46.25% (37/80) of breast cancer patients (Grade 1 = 9, Grade 2 = 37, Grade 3 = 34). Lymphovascular (LVI) and perineural invasion (PNI) were predominantly without LVI and PVI. (Lymphovascular present and perineural invasion present = 4, Lymphovascular present and perineural invasion absent = 32, Lymphovascular absent and perineural invasion absent = 42, Lymphovascular absent and perineural invasion present = 2). Histological examination of axillary lymph nodes showed the presence of malignant cells in all. Triple-negative breast carcinoma was 26.58% (21/79). Most breast cancer presented at stage II A = 37.5% (30/80) and II B = 28.7% (23/80) of the AJCC staging system. Conclusion: The clinico-epidemio and histological profile of breast cancer in Chhattisgarh is similar to other parts of India. Scarff Bloom Richardson Grade was predominantly grade 2 in 46.25% (37/80) contrary to Grade III (70%) in other series from India.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=9;spage=1923;epage=1930;aulast=Srivastavabreast cancerbreast diseasesbreast cancer epidemiologybreast cancer screeningcentral indiachhattisgarhcancer registrymammographymastectomyself-breast examinationtriple-negative breast cancer |
| spellingShingle | Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study Journal of Family Medicine and Primary Care breast cancer breast diseases breast cancer epidemiology breast cancer screening central india chhattisgarh cancer registry mammography mastectomy self-breast examination triple-negative breast cancer |
| title | Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study |
| title_full | Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study |
| title_fullStr | Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study |
| title_full_unstemmed | Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study |
| title_short | Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study |
| title_sort | clinicopathological profile of breast cancer from chhattisgarh india a single center hospital based study |
| topic | breast cancer breast diseases breast cancer epidemiology breast cancer screening central india chhattisgarh cancer registry mammography mastectomy self-breast examination triple-negative breast cancer |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2023;volume=12;issue=9;spage=1923;epage=1930;aulast=Srivastava |
| work_keys_str_mv | AT nirajkumarsrivastava clinicopathologicalprofileofbreastcancerfromchhattisgarhindiaasinglecenterhospitalbasedstudy AT sunitasingh clinicopathologicalprofileofbreastcancerfromchhattisgarhindiaasinglecenterhospitalbasedstudy AT debajyotimohanty clinicopathologicalprofileofbreastcancerfromchhattisgarhindiaasinglecenterhospitalbasedstudy AT nughathussain clinicopathologicalprofileofbreastcancerfromchhattisgarhindiaasinglecenterhospitalbasedstudy |